Immune system and hepatitis B virus infection
Immune system and hepatitis B virus infection
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DOI：
10.1016/s1386-6532(05)80009-5
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发表时间：
2005-12-01
影响因子：
8.8
通讯作者：
Lau, George K. K.
中科院分区：
文献类型：
--
作者：
Hui, Chee-Kin;Lau, George K. K.
免疫系统在决定B型肝炎病毒（HBV）感染的结果中起着重要作用。这是因为从急性HBV感染中恢复与适应性免疫应答谱的明确划分相关。在从急性HBV感染中恢复的患者中可以观察到具有1型细胞因子产生的多特异性抗病毒CD4和CD8应答。另一方面，那些发展为慢性感染的人往往具有弱的病毒特异性T细胞反应。旨在纠正这种缺陷性T细胞反应性的治疗策略可能是治疗慢性HBV感染的补充方法。(C)2005 Elsevier B.V.保留所有权利。
The immune system plays an important role in determining the outcome of hepatitis B virus (HBV) infection. This is because recovery from of acute HBV infection is associated with a clear division in the profile of adaptive immune response. Multispecific antiviral CD4 and CD8 responses with a type 1 cytokine production can be observed in patients who recover from acute HBV infection. On the other hand, those who develop chronic infection tend to have a weak virus specific T cell response. Therapeutic strategies aimed at correcting this defective T cell reactivity could represent a complementary approach to the cure of chronic HBV infection. (C) 2005 Elsevier B.V. All rights reserved.