Reliability of fMRI for studies of language in post-stroke aphasia subjects
Reliability of fMRI for studies of language in post-stroke aphasia subjects
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DOI：
10.1016/j.neuroimage.2008.02.033
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发表时间：
2008-06-01
期刊：
影响因子：
5.7
通讯作者：
Holland, Scott K.
中科院分区：
文献类型：
--
作者：
Eaton, Kenneth P.;Szaflarski, Jerzy P.;Holland, Scott K.
随着时间的推移，量化与中风后恢复和语言功能重组相关的大脑激活模式的变化需要准确理解扫描间和受试者间的变异性。在这里，我们报告了4名健康对照和4名失语症左大脑中动脉（LMCA）卒中受试者的动词生成（VG）和语义决策/音调决策（SDTD）任务相关的fMRI激活模式的扫描间变异性测量。在4 T Varian扫描仪上对每个受试者的每个任务完成一系列10次fMRI扫描，除了一名中风受试者完成了5次和6次SDTD和VG扫描外，因此分别产生了35次和36次SDTD和VG的总中风受试者扫描。组复合和组内相关系数（ICC）地图计算所有科目和试验的每项任务。VG和SDTD任务的可靠激活模式与健康和失语症受试者通常由这些任务激活的区域相对应。在对照组和失语症受试者中，个体任务的激活ICC始终较高（R-0.05约为0.8）。这些可靠性的体素方面的措施突出显示控制和恢复后中风受试者的语言回路内的低扫描间变异性区域。与单个任务的ICC相比，对照组和失语症受试者的SDTD/VG数据组合计算的ICC明显减少。这些定量测量扫描间的变异性支持建议使用这些功能磁共振成像范式的纵向映射的神经重组的语言处理后左半球的侮辱。(c)2008年爱思唯尔公司All rights reserved.
Quantifying change in brain activation patterns associated with post-stroke recovery and reorganization of language function over time requires accurate understanding of inter-scan and inter-subject variability. Here we report inter-scan variability measures for fMRI activation patterns associated with verb generation (VG) and semantic decision/tone decision (SDTD) tasks in 4 healthy controls and 4 aphasic left middle cerebral artery (LMCA) stroke subjects. A series of 10 fMRI scans was completed on a 4T Varian scanner for each task for each subject, except for one stroke subject who completed 5 and 6 scans for SDTD and VG, thus yielding 35 and 36 total stroke subject scans for SDTD and VG, respectively. Group composite and intraclass correlation coefficient (ICC) maps were computed across all subjects and trials for each task. The patterns of reliable activation for the VG and SDTD tasks correspond well to those regions typically activated by these tasks in healthy and aphasic subjects. ICCs for activation were consistently high (R-0.05 approximate to 0.8) for individual tasks among both control and aphasic subjects. These voxel-wise measures of reliability highlight regions of low inter-scan variability within language circuitry for control and post-recovery stroke subjects. ICCs computed from the combination of the SDTD/VG data were markedly reduced for both control and aphasic subjects as compared with the ICCs for the individual tasks. These quantitative measures of inter-scan variability support the proposed use of these fMRI paradigms for longitudinal mapping of neural reorganization of language processing following left hemispheric insult. (c) 2008 Elsevier Inc. All rights reserved.