Clinical impact of recreational drug use among people living with HIV in southern Taiwan
Clinical impact of recreational drug use among people living with HIV in southern Taiwan
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DOI：
10.1016/j.jmii.2020.07.016
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发表时间：
2021-10-15
影响因子：
7.4
通讯作者：
Lu, Po-Liang
中科院分区：
文献类型：
--
作者：
Chen, Guan-Lin;Lin, Shang-Yi;Lu, Po-Liang
背景：娱乐性吸毒对HIV感染者依从性、药物相互作用和性传播疾病(STDS)发生的影响尚不清楚。材料和方法：2016年12月至2018年7月进行了一项回顾性研究，以评估娱乐药物消费对接受抗逆转录病毒治疗的艾滋病毒携带者的临床影响。我们收集了人口统计学、娱乐用药、实验室结果和性病诊断的数据。用参考数据库检查潜在的药物-药物相互作用。评估娱乐用药与性传播疾病、HIV病毒载量抑制和药物相互作用之间的关系。结果：共纳入462人，其中娱乐性吸毒者384人，非娱乐性吸毒者78人。较年轻的年龄(调整后的优势比为0.94；95%CI：0.91-0.98；p=0.001)，较长的艾滋病毒感染期(调整后的优势比为1.11；95%CI：1.03-1.2；p=0.009)和较差的抗逆转录病毒药物依从性(每月丢失1-2粒抗逆转录病毒药物：AOR，6.82；95%CI：3.5-13.27；p<；0.001；；每月丢失2粒：aOR，3.5；95%CI：1.28-9.61；P=0.015)是娱乐性吸毒的相关因素。甲基苯丙胺和亚硝酸盐是两种最常见的娱乐毒品。在一年的随访期内，娱乐性吸毒与性传播疾病显著相关(AOR2.43；95%CI：1.11-5.32；p=0.027)，但与未抑制的病毒载量无显著关联，尽管有趋势(OR，2.23；95%CI：0.92-5.37；p=0.074)。与娱乐药物的潜在相互作用包括331%的抗逆转录病毒药物和31.3%的共病药物。结论：娱乐性毒品与性传播疾病有关。很大一部分服用娱乐药物的患者可能与抗逆转录病毒药物和治疗合并症的药物发生相互作用。娱乐用药与病毒载量未受抑制之间的关系值得进一步研究。版权所有2020，台湾微生物学会。爱思唯尔台湾有限责任公司出版。这是一篇CC BY-NC-ND许可证(http://creativecommons.org/licenses/by-NC-ND/4.0/)下的开放获取文章。
Background: It is unclear about the impact of recreational drug use on the adherence, drug-drug interaction and the occurrence of sexual transmitted diseases (STDs) among people living with HIV. Material and methods: A retrospective study was conducted between Dec 2016, and July 2018 to assess the clinical impact of recreational drug consumption in people living with HIV with antiretroviral therapy. We collected data of the demographics, recreational drug use, laboratory results and STDs diagnoses. Potential drug-drug interactions were checked with reference databases. The association between recreational drug use and STDs, HIV viral load suppression and drug interactions were evaluated. Results: A total of 462 participants were enrolled, included 384 recreational drug users and 78 non-recreational drug users. Younger age (adjusted odds ratio [aOR], 0.94; 95% CI: 0.91-0.98; p = 0.001), longer HIV infection period (aOR, 1.11; 95% CI: 1.03-1.20; p = 0.009) and poor antiretroviral drug adherence (1-2 pills missing per month: aOR, 6.82; 95% CI: 3.50-13.27; p < 0.001; >2 pills missing per month: aOR, 3.50; 95% CI: 1.28-9.61; p = 0.015) were factors associated with recreational drug use. Methamphetamine and nitrites were two most common recreational drugs. Recreational drug use was significantly associated with STDs in one-year follow-up period (aOR, 2.43; 95% CI: 1.11-5.32; p = 0.027) but was not significantly associated with unsuppressed viral load, though a trend was observed (OR, 2.23; 95% CI: 0.92-5.37; p = 0.074). Potential interactions with recreational drugs included 33.1% antiretroviral drugs and 31.3% medications for comorbidities. Conclusion: Recreational drug was associated with STDs. A great proportion of the patients consuming recreational drugs had potential interactions with antiretroviral drugs and medica- tions for comorbidities. The association of recreational drug use and unsuppressed viral load warrants further investigation. Copyright 2020, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by- nc-nd/4.0/).