Spectrum of neurological diseases associated with antibodies to minor gangliosides GM1b and GalNAc-GD1a
Spectrum of neurological diseases associated with antibodies to minor gangliosides GM1b and GalNAc-GD1a
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DOI：
10.1016/j.jneuroim.2006.04.005
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发表时间：
2006-08-01
影响因子：
3.3
通讯作者：
Yuki, N.
中科院分区：
文献类型：
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作者：
Tatsumoto, M.;Koga, M.;Yuki, N.
作者报告了与抗次要神经节苷脂GM 1b和Ga 1 NAc-GD 1a自身抗体相关的神经系统疾病谱。在来自7000名患有各种神经系统疾病的连续患者的血清中研究了针对神经节苷脂GM 1、GM 2、GM 1b、GD 1a、Ga 1 NAc-GD 1a和GQ 1b的IgG和IgM抗体反应性。456例抗GM 1b阳性患者的临床诊断为格林-巴利综合征（GBS，71%）、保留深腱反射的非典型GBS（12%）、Fisher综合征（10%）、Bickerstaff脑干脑炎（2%）、共济失调性GBS（2%）和急性眼肌轻瘫（1%）。在193例抗GalNAc-GD Ia阳性患者中，诊断为GBS（70%），非典型GBS（16%），Fisher综合征（10%）和Bickerstaff脑干脑炎（3%）。在GBS或非典型GBS患者中，381例抗GM 1b阳性患者中有28%和166例抗GalNAc-GD 1a阳性患者中有31%既无抗GM 1抗体也无抗GD 1a抗体。在Fisher综合征、Bickerstaff脑干脑炎、共济失调性GBS或急性眼轻瘫患者中，67例抗GM 1b阳性患者中有33%和25例抗GalNAc-GD 1a阳性患者中有52%没有抗GQ 1b抗体。抗GM 1b和GalNAc-GD 1a的自身抗体与GBS、Fisher综合征和相关疾病相关。这些抗体应该提供有用的血清学标记物，用于识别具有保留的深腱反射的非典型GBS、共济失调GBS、Bickerstaff脑干脑炎或急性眼麻痹的患者，特别是对于那些没有GM 1、GD 1a或GM 1b抗体的患者。建立了一种制备GM 1b的方法。(c)2006 Elsevier B. V.保留所有权利。
The authors reported the neurological disease spectrum associated with autoantibodies against minor gangliosides GM1b and Ga1NAc-GD1a. IgG and IgM antibody reactivity against gangliosides GM1, GM2, GM1b, GDla, Ga1NAc-GD1a and GQ1b was investigated in sera from 7000 consecutive patients who had various neurological conditions. The clinical diagnoses for 456 anti-GM1b-positive patients were Guillain-Barre syndrome (GBS, 71%), atypical GBS with preserved deep tendon reflexes (12%), Fisher syndrome (10%), Bickerstaff's brainstem encephalitis (2%), ataxic GBS (2%) and acute ophthalmoparesis (1%). For 193 anti-GalNAc-GD I a-positive patients, the diagnoses were GBS (70%), atypical GBS (16%), Fisher syndrome (10%) and Bickerstaff's brainstem encephalitis (3%). Of the patients with GBS or atypical GBS, 28% of 381 anti-GM1b-positive and 31% of 166 anti-GalNAc-GD1a-positive patients had neither anti-GM1 nor anti-GDla antibodies. Of those patients with Fisher syndrome, Bickerstaff's brainstem encephalitis, ataxic GBS or acute ophthalmoparesis, 33% of 67 anti-GM1b-positive, and 52% of 25 anti-GalNAc-GD1a-positive patients had no anti-GQ1b antibodies. Autoantibodies against GM1b and GalNAc-GD1a are associated with GBS, Fisher syndrome and related conditions. These antibodies should provide useful serological markers for identifying patients who have atypical GBS with preserved deep tendon reflexes, ataxic GBS, Bickerstaff's brainstem encephalitis or acute ophthalmoparesis, especially for those who have no antibodies to GM 1, GD1a or GM1b. A method to prepare GM1b was developed. (c) 2006 Elsevier B.V. All rights reserved.