Biological Variation in Skin Barrier Function: From A (Atopic Dermatitis) to X (Xerosis)
Biological Variation in Skin Barrier Function: From A (Atopic Dermatitis) to X (Xerosis)
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DOI：
10.1159/000441545
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发表时间：
2016-01-01
期刊：
影响因子：
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通讯作者：
Danby, Simon G.
中科院分区：
文献类型：
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作者：
Danby, Simon G.
由角质层形成的皮肤屏障包裹着我们的身体并提供重要的保护功能。然而，由于生物变异，这种屏障功能在个体之间存在差异。这种变异是由于遗传变异、负面环境或外在因素以及年龄而产生的。多种基因变化决定了一个人对皮肤屏障缺陷的易感性，从而决定了他们患上干燥皮肤病（例如特应性皮炎）的风险。外部因素，包括天气和有害的皮肤护理实践，与这些基因变化相互作用，以确定缺陷的严重程度，并进一步增加出现皮肤干燥状况的风险。这些干燥皮肤状况在临床上的表现以及它们如何持续和进展在很大程度上取决于一个人的年龄。了解皮肤屏障如何在个体之间变化、它如何根据临床表现而变化以及它如何随着年龄而变化，对于开发最佳疗法以保持健康的皮肤提供最佳保护非常重要。 (C) 2016 S. Karger AG，巴塞尔
The skin barrier, formed by the stratum corneum, envelops our bodies and provides an essential protective function. However, this barrier function differs between individuals due to biological variation. This variation arises as a result of inherited genetic variants, negative environmental or extrinsic factors, and age. A multitude of genetic changes determine a person's predisposition to a skin barrier defect and consequently their risk of developing a dry skin condition, such as atopic dermatitis. Extrinsic factors, including the weather and detrimental skin care practices, interact with these genetic changes to determine the severity of the defect and additively increase the risk of developing dry skin conditions. How these dry skin conditions present clinically, and how they persist and progress depends very much on a person's age. Understanding how the skin barrier varies between individuals, how it differs based on clinical presentation, and how it alters with age is important in developing optimum therapies to maintain healthy skin that provides the best protection. (C) 2016 S. Karger AG, Basel