Comprehensive mapping of immune perturbations associated with severe COVID-19
Comprehensive mapping of immune perturbations associated with severe COVID-19
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DOI：
10.1126/sciimmunol.abd7114
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发表时间：
2020-07-01
影响因子：
24.8
通讯作者：
Betts, Michael R.
中科院分区：
文献类型：
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作者：
Kuri-Cervantes, Leticia;Pampena, Maria Betina;Betts, Michael R.
尽管危重疾病与SARS-CoV-2诱导的过度炎症有关，但严重COVID-19的免疫相关性仍不清楚。在这里，我们全面分析了42例SARS-CoV-2感染和康复者的外周血免疫紊乱。我们发现了多种免疫谱系的广泛诱导和激活，包括T细胞激活、寡克隆浆母细胞扩增以及先天淋巴细胞和粒细胞上的Fc和运输受体调节，这些免疫谱系将严重COVID-19病例与健康供体或SARS-CoV-2康复或中度严重患者区分开来。我们发现嗜中性粒细胞与淋巴细胞的比率是疾病严重程度和器官衰竭的预后生物标志物。我们的研究结果表明，广泛的先天性和适应性白细胞扰动，区分严重的SARSCoV-2感染失调的宿主反应，并保证治疗调查。
Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood immune perturbations in 42 SARS-CoV-2-infected and -recovered individuals. We identified extensive induction and activation of multiple immune lineages, including T cell activation, oligoclonal plasmablast expansion, and Fc and trafficking receptor modulation on innate lymphocytes and granulocytes, that distinguished severe COVID-19 cases from healthy donors or SARS-CoV-2-recovered or moderate severity patients. We found the neutrophil-to-lymphocyte ratio to be a prognostic biomarker of disease severity and organ failure. Our findings demonstrate broad innate and adaptive leukocyte perturbations that distinguish dysregulated host responses in severe SARSCoV-2 infection and warrant therapeutic investigation.