Super pH-sensitive multifunctional polymeric micelle
Super pH-sensitive multifunctional polymeric micelle
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DOI：
10.1021/nl0479987
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发表时间：
2005-02-01
期刊：
影响因子：
10.8
通讯作者：
Bae, YH
中科院分区：
文献类型：
--
作者：
Lee, ES;Na, K;Bae, YH
为了赋予载体增强的肿瘤特异性和内体破坏性质，研究了多功能聚合物胶束。胶束在各种实体瘤的微酸性环境条件下暴露表面上的细胞相互作用配体（生物素），并在短时间内通过生物素受体介导的内吞作用内化。胶束也表现出pH依赖性的解离，导致增强释放阿霉素从载体在早期的内体pH值。解离的胶束组分随后破坏内体膜。
To endow enhanced tumor specificity and endosome disruption property on the carrier, a multifunctional polymeric micelle was investigated. The micelle exposes the cell interacting ligand (biotin) on the surface under slightly acidic environmental conditions of various solid tumors and is internalized by biotin receptor-mediated endocytosis in a short time period. The micelle also showed pH-dependent dissociation, causing the enhanced release of doxorubicin from the carrier in early endosomal pH. The dissociated micellar components subsequently disrupt endosomal membrane.