Degree of inhibition of cortical acetylcholinesterase activity and cognitive effects by donepezil treatment in Alzheimer's disease
Degree of inhibition of cortical acetylcholinesterase activity and cognitive effects by donepezil treatment in Alzheimer's disease
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DOI：
10.1136/jnnp.2004.038729
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发表时间：
2005-03-01
影响因子：
11
通讯作者：
Moore, RY
中科院分区：
文献类型：
--
作者：
Bohnen, NI;Kaufer, DI;Moore, RY
目的：确定轻度阿尔茨海默病受试者体内皮质乙酰胆碱酯酶（AChE）活性和认知效应方法：认知和N-[C-11]甲基-哌啶-4-基丙酸酯（[C-11]PMP）AChE正电子发射断层扫描（PET）在多奈哌齐治疗前后的评估。PET数据分析显示，平均（颞叶、顶叶和额叶）皮质多奈哌齐诱导的AChE抑制率为19.1%（SD 9.4%）（t= -7.9; p
Objectives: To determine in vivo cortical acetylcholinesterase (AChE) activity and cognitive effects in subjects with mild Alzheimer's disease (AD, n = 14) prior to and after 12 weeks of donepezil therapy.Methods: Cognitive and N-[C-11]methyl-piperidin-4-yl propionate ([C-11]PMP) AChE positron emission tomography (PET) assessments before and after donepezil therapy.Results: Analysis of the PET data revealed mean (temporal, parietal, and frontal) cortical donepezil induced AChE inhibition of 19.1% (SD 9.4%) (t= -7.9; p