MR OF NEURONAL MIGRATION ANOMALIES
MR OF NEURONAL MIGRATION ANOMALIES
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DOI：
10.2214/ajr.150.1.179
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发表时间：
1988-01-01
影响因子：
5
通讯作者：
NORMAN, D
中科院分区：
文献类型：
--
作者：
BARKOVICH, AJ;CHUANG, SH;NORMAN, D
迁移异常是在妊娠第三至第五个月期间由于迁移的神经母细胞受到损伤而引起的先天性畸形。包括无脑回畸形、厚脑回畸形、多小脑回畸形、单侧巨脑畸形、中脑畸形和灰质异位。患有这些疾病的患者在临床上表现为发育迟缓和癫痫发作，并且在受影响更严重的婴儿中注意到运动技能异常。为了确定MR作为这些患者成像方法的实用性，我们使用MR对13例具有全谱移位异常的患者进行了评价。MR在发现这些异常方面比CT更敏感，因为它在灰色和白色物质之间有更好的对比。我们发现，MR在检测回脑畸形和多脑回畸形方面尤其敏感，回脑畸形中，识别裂隙内灰质的存在对于区分该疾病和脑穿通症至关重要，而多脑回畸形中，皮质结构的关键细节在CT上被覆盖的骨骼所掩盖。多平面能力也被认为是必不可少的，因为当成像平面平行于裂缝时，可能无法检测到狭窄的裂缝。MR应该是癫痫发作或发育迟缓婴儿的主要成像方法。
Migration anomalies are congenital malformations caused by insults to migrating neuroblasts during the third to fifth gestational months. Included in this group are agyria, pachygyria, polymicrogyria, unilateral megalencephaly, schizencephaly, and gray matter heterotopias. Patients who have these conditions present clinically with developmental delay and seizures, and abnormal motor skills are noted in the more severely affected infants. To determine the utility of MR as a method for imaging in these patients, we used MR to evaluate 13 patients who had the full spectrum of migration anomalies. MR was more sensitive than CT in detecting these anomalies because of its better contrast between gray and white matter. We found that MR was particularly more sensitive in detecting schizencephaly, where recognizing the presence of gray matter lining the cleft is critical to distinguishing that disease from porencephaly, and in detecting polymicrogyria, where critical details of cortical architecture are obscured on CT by the overlying bone. Multiplanar capabilities were also found to be essential, since narrow clefts may not be detected when the imaging plane is parallel to the cleft. MR should be the primary imaging method for infants who have seizures or developmental delay.