What can we hope to gain for trypanosomiasis control from molecular studies on tsetse biology ?
What can we hope to gain for trypanosomiasis control from molecular studies on tsetse biology ?
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我们希望从针对采集生物学的分子研究中控制锥虫病？
DOI：
10.1186/1475-9292-1-4
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发表时间：
2002-06-06
期刊：
影响因子：
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通讯作者：
Strickler, Patricia M
中科院分区：
文献类型：
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作者：
Aksoy, Serap;Hao, Zhengrong;Strickler, Patricia M
在疫情肆虐并开始对受影响人口造成损害的危机时期，就像我们在撒哈拉以南目睹的非洲锥虫病一样，基础研究和应用研究的二分法加深了。尽管治疗数以千计的感染者无疑是当务之急，但如果不继续研究和发展病原体生物学以及影响这些流行病的生态和进化力量，从长远来看，在最终控制这些疾病方面取得的进展微乎其微。在这里，我们认为有必要在一个研究不足的领域进行进一步的研究，那就是采采集媒介的生物学。缺乏旨在了解采采赛与锥虫相互作用的遗传和细胞基础，以及其传播这些寄生虫能力的遗传和生化基础的研究。我们讨论了这些知识如何有可能有助于新的媒介控制策略的发展，以及如何提高现有控制方法的有效性和可负担性。
At times of crisis when epidemics rage and begin to take their toll on affected populations, as we have been witnessing with African trypanosomiasis in subSahara, the dichotomy of basic versus applied research deepens. While undoubtedly the treatment of thousands of infected people is the top priority, without continued research and development on the biology of disease agents and on ecological and evolutionary forces impacting these epidemics, little progress can be gained in the long run for the eventual control of these diseases. Here, we argue the need for additional research in one under-investigated area, that is the biology of the tsetse vector. Lacking are studies aimed to understand the genetic and cellular basis of tsetse interactions with trypanosomes as well as the genetic and biochemical basis of its ability to transmit these parasites. We discuss how this knowledge has the potential to contribute to the development of new vector control strategies as well as to improve the efficacy and affordability of the existing control approaches.