The use of P300-based BCIs in amyotrophic lateral sclerosis: from augmentative and alternative communication to cognitive assessment.
The use of P300-based BCIs in amyotrophic lateral sclerosis: from augmentative and alternative communication to cognitive assessment.
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DOI：
10.1002/brb3.57
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发表时间：
2012-07
影响因子：
3.1
通讯作者：
Riva, Giuseppe
中科院分区：
文献类型：
--
作者：
Cipresso, Pietro;Carelli, Laura;Solca, Federica;Meazzi, Daniela;Meriggi, Paolo;Poletti, Barbara;Lule, Dorothee;Ludolph, Albert C.;Silani, Vincenzo;Riva, Giuseppe
关键词：
在肌萎缩侧索硬化症（ALS）患者中使用增强和替代性交流（AAC）工具作为补偿语言和手势交流逐渐丧失的有效手段，在最近的文献中已进行了深入研究。先进的AAC系统的发展，如眼动追踪（ET）和脑机接口（BCI）设备，允许绕过ALS患者存在的重要运动困难。特别是，BCI可以用于疾病的中度至重度阶段，因为它们不需要保留眼运动能力，而这是ET应用所必需的。此外，一些研究已经证明了BCI的可靠性，无论疾病的严重程度和身体衰退的程度如何。然而，在ALS患者中使用BCI仍然显示出一些局限性，与技术和神经心理学问题有关。特别是，在大多数ALS患者中观察到一系列认知缺陷。目前，没有有效的语言-运动自由措施可用于评估ALS患者的认知完整性; BCI可以提供一种新的可能性，无需语言或运动反应即可管理认知任务，这一领域的初步研究强调了这一点。在这篇综述中，我们概述了脑机接口系统的基本特征，考虑到这些工具的优势和挑战，ALS患者和在这一领域开发的主要应用。然后，我们概述了在ALS中观察到的认知缺陷方面的主要研究结果，以及通过脑机接口对其进行评估的一些初步尝试。对特定认知特征的定义有助于根据患者的需求制定灵活的方法。它可以提高脑机接口的效率，减少患者的努力。最后，我们处理开放的问题，代表使用脑机接口与完全锁定的患者，谁似乎无法可靠地学习使用这种工具。
The use of augmentative and alternative communication (AAC) tools in patients with amyotrophic lateral sclerosis (ALS), as effective means to compensate for the progressive loss of verbal and gestural communication, has been deeply investigated in the recent literature. The development of advanced AAC systems, such as eye-tracking (ET) and brain-computer interface (BCI) devices, allowed to bypass the important motor difficulties present in ALS patients. In particular, BCIs could be used in moderate to severe stages of the disease, since they do not require preserved ocular-motor ability, which is necessary for ET applications. Furthermore, some studies have proved the reliability of BCIs, regardless of the severity of the disease and the level of physical decline. However, the use of BCI in ALS patients still shows some limitations, related to both technical and neuropsychological issues. In particular, a range of cognitive deficits in most ALS patients have been observed. At the moment, no effective verbal-motor free measures are available for the evaluation of ALS patients’ cognitive integrity; BCIs could offer a new possibility to administer cognitive tasks without the need of verbal or motor responses, as highlighted by preliminary studies in this field. In this review, we outline the essential features of BCIs systems, considering advantages and challenges of these tools with regard to ALS patients and the main applications developed in this field. We then outline the main findings with regard to cognitive deficits observed in ALS and some preliminary attempts to evaluate them by means of BCIs. The definition of specific cognitive profiles could help to draw flexible approaches tailored on patients’ needs. It could improve BCIs efficacy and reduce patients’ efforts. Finally, we handle the open question, represented by the use of BCIs with totally locked in patients, who seem unable to reliably learn to use such tool.
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影响因子：
4.3
作者：
Brouwer AM;van Erp JB
通讯作者：
van Erp JB
影响因子：
9.9
作者：
Abrahams, S;Leigh, PN;Goldstein, LH
通讯作者：
Goldstein, LH
影响因子：
3.4
作者：
DAVID, AS;GILLHAM, RA
通讯作者：
GILLHAM, RA
影响因子：
4
作者：
Citi, Luca;Poli, Riccardo;Cinel, Caterina
通讯作者：
Cinel, Caterina
DOI：
10.1109/86.847808
发表时间：
2000-06-01
期刊：
IEEE TRANSACTIONS ON REHABILITATION ENGINEERING
影响因子：
--
作者：
Donchin, E;Spencer, KM;Wijesinghe, R
通讯作者：
Wijesinghe, R