Lower-Limb Vascular Imaging with Acoustic Radiation Force Elastography: Demonstration of In Vivo Feasibility
Lower-Limb Vascular Imaging with Acoustic Radiation Force Elastography: Demonstration of In Vivo Feasibility
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DOI：
10.1109/tuffc.2009.1126
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发表时间：
2009-05-01
影响因子：
3.6
通讯作者：
Trahey, Gregg
中科院分区：
文献类型：
--
作者：
Dumont, Douglas;Dahl, Jeremy;Trahey, Gregg
声辐射力脉冲（ARFI）成像通过测量由施加的超声辐射力引起的位移来表征组织的机械特性。在本文中，我们描述了ARFI成像下肢血管应用的现状，并提出了组织模拟体模和体内实验的结果。初步的实验是在聚乙烯醇血管模型上进行的。采用ARFI成像技术对多层血管和不同斑块负荷的顺应性闭塞血管进行评价。体模层和斑块在ARFI图像中得到很好的分辨，具有比B模式更高的对比度，证明了ARFI成像识别不同机械特性区域的能力。对健康人受试者和诊断为下肢外周动脉疾病的受试者进行成像。近端和远端血管壁在ARFI图像中可视化良好，平均对比度高于相应的B模式图像。ARFI图像揭示了常规超声无法观察到的信息，并为下肢血管检查期间使用ARFI成像的可行性提供了信心。
Acoustic radiation force impulse (ARFI) imaging characterizes the mechanical properties of tissue by measuring displacement resulting from applied ultrasonic radiation force. In this paper, we describe the current status of ARFI imaging for lower-limb vascular applications and present results from both tissue-mimicking phantoms and in vivo experiments. Initial experiments were performed on vascular phantoms constructed with polyvinyl alcohol for basic evaluation of the modality. Multilayer vessels and vessels with compliant occlusions of varying plaque load were evaluated with ARFI imaging techniques. Phantom layers and plaque are well resolved in the ARFI images, with higher contrast than B-mode, demonstrating the ability of ARFI imaging to identify regions of different mechanical properties. Healthy human subjects and those with diagnosed lower-limb peripheral arterial disease were imaged. Proximal and distal vascular walls are well visualized in ARFI images, with higher mean contrast than corresponding B-mode images. ARFI images reveal information not observed by conventional ultrasound and lend confidence to the feasibility of using ARFI imaging during lower-limb vascular workup.