Does treatment with ARA-C in low dosage cause differentiation of leukemic cells?
Does treatment with ARA-C in low dosage cause differentiation of leukemic cells?
复制标题
低剂量ARA-C治疗是否会导致白血病细胞分化？
DOI：
10.1182/blood.v62.1.85.85
复制
发表时间：
1983
期刊：
影响因子：
20.3
通讯作者：
L. Degos
中科院分区：
文献类型：
--
作者：
S. Castaigne;M. Daniel;H. Tilly;P. Hérait;L. Degos
A series of 21 patients (5 refractory anemias with an excess of blasts in transformation and 16 acute leukemias) were treated with small doses of ARA-C (10 mg/sq m/12 hr for 15-21 days). Improvement was noted in 15 cases (71%) and complete remission observed in 12 (57%). Complete remission was obtained after one course of treatment in 8 cases. The fact that these patients entered remission relatively slowly and did not suffer marrow aplasia suggests that low-dose ARA-C may function in vivo as it does in vitro, i.e., by inducing differentiation of leukemic blasts.
