Peritumoral CD1a-positive dendritic cells are associated with improved survival in patients with tongue carcinoma
Peritumoral CD1a-positive dendritic cells are associated with improved survival in patients with tongue carcinoma
复制标题
DOI：
10.1001/archotol.124.6.641
复制
发表时间：
1998-06-01
影响因子：
--
通讯作者：
Lotze, MT
中科院分区：
文献类型：
--
作者：
Goldman, SA;Baker, E;Lotze, MT
目的：探讨舌鳞状细胞癌患者的生存率和复发率是否与原发灶或邻近舌组织的树突状细胞(DC)浸润程度相关，以及肿瘤或淋巴结分期是否与DC浸润有关。设计：回顾医院和办公室的医疗记录，获得5年的随访数据。原发病理标本复查，进行细胞表面标记S100和CD1a染色。标本中DC的数量通过显微镜进行量化，并与患者的预后和分期进行统计学比较。地点：一所大学医院。患者：所有从1987年1月1日至1990年12月31日接受原发舌鳞状细胞癌切除术的患者(N=43)。主要观察指标：复发、死亡或两者兼而有之的时间。结果：肿瘤旁CD1a阳性的DC数量越多，患者的生存时间越长(P=0.02)，复发率越低(P=0.06)。研究的其他DC亚群与生存或复发无关。此外，随着肿瘤分期的增加(P=.01)和有无淋巴结转移(P=.05)，瘤周上皮细胞中CD1a阳性的DC数量减少。结论：树突状细胞是一种抗原提呈细胞，在抗肿瘤免疫反应中发挥重要作用。CD1a表面抗原已被证明可以介导T细胞之间的相互作用。CD1a阳性的瘤周树突状细胞与患者预后之间的关系提示了这一细胞群的重要功能。
Objectives: To determine if survival and recurrence rates for patients with squamous cell carcinoma of the tongue correlate with the degree of dendritic cell (DC) infiltration of the primary tumor or adjacent tongue tissue and if there is an association between tumor or nodal stage and DC infiltration.Design: Hospital and office medical records were reviewed to obtain 5-year follow-up data. Original pathology specimens were recur and stained for the cell surface markers S100 and CD1a. The number of DCs present in the specimens was quantified microscopically and compared statistically with patient outcome and staging.Setting: A university hospital.Patients: All patients who underwent resection of primary squamous cell carcinoma of the tongue from January 1, 1987, through December 31, 1990, for whom 5-year follow-up data and original pathology specimens were available (N=43).Main Outcome Measures: Time to recurrence, death, or both.Results: Patients who had greater numbers of CD1a positive DCs adjacent to tumor had improved survival (P = .02) and decreased recurrence rates (P = .06). The other subpopulations of DCs examined were not associated with survival or recurrence. In addition, the number of CD1a-positive DCs in peritumoral epithelium decreased as the tumor stage increased (P = .01) and if nodal metastases were present (P = .05).Conclusions: Dendritic cells are antigen-presenting cells that are thought to play a major role in the antitumor immune response. The CD1a surface antigen has been shown to mediate T-cell interactions. The association between CD1a-positive peritumoral DCs and patient outcome suggests an important function for this cell population.