Impaired nocturnal synthesis of melatonin in patients with cardiac syndrome X
Impaired nocturnal synthesis of melatonin in patients with cardiac syndrome X
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DOI：
10.1016/s0304-3940(02)00368-3
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发表时间：
2002-07-19
影响因子：
2.5
通讯作者：
Ozbay, G
中科院分区：
文献类型：
--
作者：
Altun, A;Yaprak, M;Ozbay, G
我们研究了心脏X综合征患者和健康人夜间褪黑激素的分泌模式。本研究在5名心脏X综合征患者和9名健康对照中进行。所有受试者在22：00~08：00之间每隔2小时采血一次，用放射免疫试剂盒检测褪黑素水平。心脏X综合征患者夜间2：00h褪黑激素分泌量低于对照组(P=0.04)。心脏X综合征患者血清褪黑素峰值和峰值均低于正常对照组(P=0.039和P=0.028)。总而言之，心脏X综合征患者夜间褪黑激素合成明显减少。我们的研究提供了心脏X综合征患者褪黑素合成和释放的有用信息，可能有助于医生对这些患者的治疗。(C)2002年，爱思唯尔科学爱尔兰有限公司出版。
We investigated nocturnal secretion pattern of melatonin in patients with cardiac syndrome X and healthy subjects. The present study performed in five patients with cardiac syndrome X and in nine healthy controls. Blood samples from all subjects were collected every 2 h intervals between 22:00 and 08:00 h. Melatonin levels were measured with a radioimmunoassay kit. Patients with cardiac syndrome X secreted less nocturnal melatonin at 02:00 h than control subjects (P = 0.04). Peak and Delta melatonin (peak-lowest melatonin) were found lower in patients with cardiac syndrome X (P = 0.039 and P = 0.028, respectively). In conclusion patients with cardiac syndrome X show a markedly decreased nocturnal melatonin synthesis. Our study provides useful information about melatonin synthesis and release in patients with cardiac syndrome X might help physicians in managing these patients. (C) 2002 Published by Elsevier Science Ireland Ltd.