Enhancement of in vivo immune response by tumor necrosis factor.
Enhancement of in vivo immune response by tumor necrosis factor.
复制标题
肿瘤坏死因子增强体内免疫反应。
DOI：
10.4049/jimmunol.139.11.3676
复制
发表时间：
1987
影响因子：
4.4
通讯作者：
A. Tagliabue
中科院分区：
文献类型：
--
作者：
P. Ghiara;D. Boraschi;L. Nencioni;P. Ghezzi;A. Tagliabue
白介素1(IL-1)对多种免疫功能有调节作用。由于肿瘤坏死因子与IL-1有许多共同的生物学特性，我们在这里研究了肿瘤坏死因子在免疫反应调节中的作用。因此，我们测试了低剂量的重组人肿瘤坏死因子-α(人源重组肿瘤坏死因子-α)在溶血空斑试验中增强体内抗体反应的能力，在细胞水平上进行了评估。研究发现，人重组肿瘤坏死因子-α和人IL-1β一样，能够增强对T细胞依赖抗原(绵羊红细胞)的免疫反应。有趣的是，与人类重组IL-1β不同，人重组肿瘤坏死因子-α不能增强体内对T细胞非依赖性抗原(III型肺炎球菌多糖)的抗体反应。这些结果表明，低水平的肿瘤坏死因子可能在体内免疫反应的调节中起作用，并为该介质的生物学意义提供了新的线索。
Interleukin 1 (IL-1) has been shown to regulate several immunologic functions. Since tumor necrosis factor (TNF) shares many biologic properties with IL-1, we have investigated here the role of TNF in the modulation of the immune response. We have thus tested low doses of human recombinant TNF-alpha (hu rTNF-alpha) for its capacity to enhance the in vivo antibody responses evaluated at the cellular level in the hemolytic plaque assay. It was found that hu rTNF-alpha, like human IL-1 beta, is able to enhance the immune response to a T cell-dependent antigen (sheep red blood cells). Interestingly, at variance with human recombinant IL-1 beta, hu rTNF-alpha was not able to enhance the in vivo antibody response to a T cell-independent antigen (type III pneumococcal polysaccharide). These results suggest that low levels of TNF may have a role in the modulation of the immune response in vivo and shed new light on the biologic significance of this mediator.