Ulcerative colitis and Sweet's syndrome: A case report and review of the literature
Ulcerative colitis and Sweet's syndrome: A case report and review of the literature
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DOI：
10.1155/2008/960585
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发表时间：
2008-03-01
期刊：
影响因子：
--
通讯作者：
Duerksen, Donald R.
中科院分区：
文献类型：
--
作者：
Ali, Massud;Duerksen, Donald R.
一名47岁男性，有强的松和硫唑嘌呤治疗的溃疡性结肠炎病史，因发热、皮疹、关节痛和白细胞增多4天入院。皮肤活检显示，真皮有中性粒细胞浸润符合斯威特综合征。几天后病情好转，泼尼松和硫唑嘌呤用量增加。Sweet’s综合征是一种罕见的炎症性肠病的皮肤表现，文献中报道了大约40例。在先前报道的一例溃疡性结肠炎相关的Sweet's综合征患者中，在皮肤爆发时正在服用硫唑嘌呤，但后来停用了硫唑嘌呤，这增加了药物引起Sweet's综合征的可能性。在本病例中，硫唑嘌呤实际上随着皮肤表现的完全解决而增加。这将支持免疫抑制疗法是治疗这种疾病的主要疗法的理论。总之，Sweet综合征是一种中性粒细胞性皮肤病，很少与溃疡性结肠炎相关。它可能在免疫抑制治疗时发生，并对免疫抑制的强化有反应。
A 47-year-old man with a history of ulcerative colitis on prednisone and azathioprine was admitted to the hospital with a four-day history of fever, skin rash, arthralgias and leukocytosis. A skin biopsy demon, strated neutrophilic infiltration of the dermis that was consistent with Sweet's syndrome. He improved after several days with an increase in his prednisone and azathioprine. Sweet's syndrome is a rare cutaneous manifestation of inflammatory bowel disease, with approximately 40 cases reported in the literature. In a previously reported case of a patient with ulcerative colitis-associated Sweet's syndrome who was on azathioprine at the time of the skin eruption, the azathioprine was stopped, raising the possibility of drug-induced Sweet's syndrome. In the present case, the azathioprine was actually increased with complete resolution of the skin manifestations. This would Support the theory that immunosuppressive therapy is the mainstay of therapy for this condition. In conclusion, Sweet's syndrome is a neutrophilic dermatosis that is rarely associated with ulcerative colitis. It may occur while on immunosuppressive therapy and responds to an intensification of immunosuppression.