Microchimerism in the transfused obstetric population.
Microchimerism in the transfused obstetric population.
复制标题
输血产科人群中的微嵌合现象。
DOI：
10.1111/vox.12177
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发表时间：
2014
期刊：
影响因子：
2.7
通讯作者：
Stefan,V
中科院分区：
文献类型：
--
作者：
Bloch,EM;Busch,MP;Lee,T-H;Montalvo,L;Matthews,Y;Bird,A;Bruhn,R;Stefan,V
微嵌合体（MC），同种异体细胞群体在宿主内的共存，在妊娠和输血中有很好的描述。迄今为止，输血相关MC（TA-MC）似乎是严重创伤后输血患者所独有的。我们试图确定围产期输血是否会导致持久的高水平TA-MC。我们对22名分娩后48小时内新输血的妇女进行了一项前瞻性队列研究。2例受试者显示出一过性TA-MC的证据;然而，在6周和6个月时未检测到MC。阴性结果表明，在该人群中不会发生持久的TA-MC。
Microchimerism (MC), the coexistence of allogeneic populations of cells within a host, is well described in pregnancy and blood transfusion. To date, transfusion‐associated MC (TA‐MC) appears unique to patients transfused after severe traumatic injury. We sought to determine whether transfusion in the peripartum period results in enduring, high‐level TA‐MC. We conducted a prospective cohort study of 22 women who were newly transfused within 48 h of delivery. Two subjects showed evidence of transient TA‐MC; however, MC was not detected at 6 weeks and 6 months. The negative findings suggest that enduring TA‐MC does not occur in this population.