Etiology of diarrhea in children younger than 5 years of age admitted in a rural hospital of southern Mozambique
Etiology of diarrhea in children younger than 5 years of age admitted in a rural hospital of southern Mozambique
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DOI：
10.4269/ajtmh.2007.76.522
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发表时间：
2007-03-01
影响因子：
3.3
通讯作者：
Gascon, Joaquim
中科院分区：
文献类型：
--
作者：
Mandomando, Inacio M.;Macete, Eusebio V.;Gascon, Joaquim
腹泻是撒哈拉以南非洲儿童发病和死亡的主要原因之一，也是农村地区住院的主要原因之一。从Manhica地区医院（2000年9月至2001年9月）收治的529名腹泻儿童中收集粪便样本，并进行处理以检测细菌性肠道病原体、寄生虫和病毒。从120份样本中分离出的致腹泻性大肠埃希菌（22.6%;肠致病性[9.6%]、肠聚集性[6.8%]、肠聚集性[4.3%]和致维罗霉素[1.9%]）是最常见的病原体，其次是蛔虫（9.3%）。其他检测到的包括沙门氏菌属。蓝氏贾第鞭毛虫（各2.5%）和弯曲杆菌属（Campylobacter spp.）(1.7%). A.在12个月以上的儿童中，最常分离出的是蛔虫（92%对8%; P < 0.001）和粪类圆线虫（100%对0%; P = 0.008）。对甲氧苄啶、磺胺甲恶唑、氨苄西林耐药率高。病原学数据和敏感性模式的真菌，病原体是重要的工具，临床管理和控制战略规划。
Diarrhea is one of the main causes of morbidity and mortality among children in sub-Saharan Africa and one of the main causes of hospital admissions in rural areas. Stool samples were collected from 529 children admitted with diarrhea to the Manhica District Hospital (September 2000 to September 2001) and processed to detect bacterial enteropathogens, parasites, and virus. Diarrheagenic Escherichia coli, isolated from 120 samples (22.6%; enteropathogenic [9.6%], enterotoxigenic [6.8%], enteroaggregative [4.3%], and verotoxigenic [1.9%]) was the most frequently isolated pathogen, followed by Ascaris lumbricoides (9.3%). Others detected included Salmonella spp. and Giardia lamblia (2.5% each) and Campylobacter spp. (1.7%). A. lumbricoides (92% versus 8%; P < 0.001) and Strongyloides stercolaris (100% versus 0%; P = 0.008) were most frequently isolated in children older than 12 months of age. Resistance to trimethoprim-sulphametoxazole and ampicillin was high. Etiologic data on diarrheal diseases and susceptibility patterns of diarrheal, pathogens are important tools for clinical management and control strategic planning.