Evaluating antimicrobials and implant materials for infection prevention around transcutaneous osseointegrated implants in a rabbit model
Evaluating antimicrobials and implant materials for infection prevention around transcutaneous osseointegrated implants in a rabbit model
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DOI：
10.1002/jbm.a.32413
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发表时间：
2010-03-01
影响因子：
4.9
通讯作者：
Bloebaum, Roy D.
中科院分区：
文献类型：
--
作者：
Chou, Teri G. Rosenbaum;Petti, Cathy A.;Bloebaum, Roy D.
经皮骨整合植入物可以改善部分截肢患者的功能，但感染是植入式经皮器械的一个重要限制。本研究在兔模型中检查了抗菌剂醋酸培西加南（SUPONEX（TM））和多孔钽植入物材料（Trabecular Metal（TM））在预防骨结合植入物针道感染方面的有效性。将37只家兔随机分为3组：钛对照组（n = 11），植入钛合金植入物，不使用抗菌剂;钛-Pexiganan组（n = 8），植入钛合金植入物，每天在皮肤/植入物界面局部应用1%醋酸pexiganan; Ta对照组（n = 18），植入多孔钽植入物，不使用抗菌剂。所有的植入物都是通过皮肤，肌肉，和骨骼植入的。监测兔的感染持续24周。与钛对照组相比，我们观察到钛-Pexiganan组的针道感染率降低了75%（p = 0.019）。Ta对照组和Ti对照组之间未观察到感染率差异（1）= 0.230）。结论：醋酸培西加南可能是经皮骨结合种植体的重要抗菌剂。多孔钽不太可能防止针道感染，如果没有植入部位周围软组织固定的额外方法。(C)2009 Wiley Periodicals，Inc.* J Biomed Mater Res 92A：942-952，2010
Transcutaneous osseointegrated implants can improve function for select amputee patients, but infection serves as a significant limitation of implantable transcutaneous devices. This study examined the efficacy of an anti-microbial, pexiganan acetate (SUPONEX (TM)), and a porous tantalum implant material (Trabecular Metal (TM)) in preventing pin tract infection of osseointegrated implants in a rabbit model. Thirty-seven rabbits Were randomized to three groups: Ti-control group (n = 11) with titanium alloy implant and no antimicrobial, Ti-Pexiganan group (n = 8) With titanium alloy implant and topical pexiganan acetate 1% applied daily at the skin/implant interface, and Ta-control group (n = 18) with porous tantalum implant and no antimicrobial. All implants Were placed transcutaneously through skin, muscle, and bone. Rabbits were monitored for infection for 24 weeks. We observed a 75% reduction in rates of pin tract infection in the Ti-Pexiganan group compared to that observed in the Ti-control group (p = 0.019). No difference in rates of infection was observed between the Ta-control group and the Ti-control group (1) = 0.230). In Conclusion, pexiganan acetate may be an important antimicrobial for transcutaneous osseointegrated implants. Porous tantalum Will not likely prevent pin tract infection Without additional methods of soft tissue immobilization around the implant site. (C) 2009 Wiley Periodicals, Inc.* J Biomed Mater Res 92A: 942-952, 2010