Combining fluorescent in situ hybridization data with ISS staging improves risk assessment in myeloma: an International Myeloma Working Group collaborative project.
Combining fluorescent in situ hybridization data with ISS staging improves risk assessment in myeloma: an International Myeloma Working Group collaborative project.
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DOI：
10.1038/leu.2012.282
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发表时间：
2013-03
期刊：
影响因子：
11.4
通讯作者：
Morgan, G.
中科院分区：
文献类型：
--
作者：
Avet-Loiseau, H.;Durie, B. G. M.;Cavo, M.;Attal, M.;Gutierrez, N.;Haessler, J.;Goldschmidt, H.;Hajek, R.;Lee, J. H.;Sezer, O.;Barlogie, B.;Crowley, J.;Fonseca, R.;Testoni, N.;Ross, F.;Rajkumar, S. V.;Sonneveld, P.;Lahuerta, J.;Moreau, P.;Morgan, G.
根据国际分期系统（ISS），血清β2-微球蛋白和白蛋白水平的组合已被证明是骨髓瘤的高度预后指标。本研究的目的是评估ISS分期和细胞遗传学异常在预测预后中的独立作用。对ISS和细胞遗传学异常的国际研究进行了回顾性分析，以评估ISS分期和细胞遗传学联合预测生存率的潜在作用。这项国际努力使用了国际骨髓瘤工作组数据库，该数据库包含全球12137例诊断时接受骨髓瘤治疗的患者，其中2309例进行了细胞遗传学研究，5387例通过荧光原位杂交（iFISH）进行了分析。综合分析使用了2642例具有足够iFISH数据的患者。使用综合iFISH数据，结合t（4;14）和缺失（17 p），沿着ISS分期，显著改善了无进展生存期和总生存期方面的预后评估。还证实了患者年龄和使用高剂量治疗的额外影响。总之，iFISH数据与ISS分期的结合显著改善了骨髓瘤的风险评估。
The combination of serum β2-microglobulin and albumin levels has been shown to be highly prognostic in myeloma as the International Staging System (ISS). The aim of this study was to assess the independent contributions of ISS stage and cytogenetic abnormalities in predicting outcomes. A retrospective analysis of international studies looking at both ISS and cytogenetic abnormalities was performed in order to assess the potential role of combining ISS stage and cytogenetics to predict survival. This international effort used the International Myeloma Working Group database of 12 137 patients treated worldwide for myeloma at diagnosis, of whom 2309 had cytogenetic studies and 5387 had analyses by fluorescent in situ hybridization (iFISH). Comprehensive analyses used 2642 patients with sufficient iFISH data available. Using the comprehensive iFISH data, combining both t(4;14) and deletion (17p), along with ISS stage, significantly improved the prognostic assessment in terms of progression-free survival and overall survival. The additional impact of patient age and use of high-dose therapy was also demonstrated. In conclusion, the combination of iFISH data with ISS staging significantly improves risk assessment in myeloma.
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影响因子：
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