Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study
Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study
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DOI：
10.1016/s1473-3099(20)30176-6
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发表时间：
2020-05-01
影响因子：
56.3
通讯作者：
Wu, Jianli
中科院分区：
文献类型：
--
作者：
Yu, Nan;Li, Wei;Wu, Jianli
背景 2019 年 12 月，中国武汉出现了由严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）引起的 2019 冠状病毒病（COVID-19）。受影响的孕妇数量正在增加，但有关妊娠期 COVID-19 临床特征的信息却很少。本研究旨在阐明 COVID-19 孕妇的临床特征以及产科和新生儿结局。 方法 在这项回顾性单中心研究中，我们纳入了中国武汉同济医院收治的所有 COVID-19 孕妇。对临床特征、治疗以及母婴结局进行了评估。结果我们的研究纳入了 2020 年 1 月 1 日至 2 月 8 日期间入住同济医院的 7 名患者。患者的平均年龄为 32 岁（范围为 29-34 岁），平均孕龄为 39 周加 1 天（范围为 37 周至 41 周加 2 天）。临床表现包括发热（6 名[86%] 患者）、咳嗽（1 名[14%] 患者）、呼吸急促（1 名[14%] 患者）和腹泻（1 名[14%] 患者）。所有患者均在临床表现后 3 天内进行剖腹产，平均孕龄为 39 周加 2 天。最终随访日期为2020年2月12日。孕妇和新生儿的结局良好。对三名新生儿进行了 SARS-CoV-2 检测，一名新生儿在出生后 36 小时感染了 SARS-CoV-2。 解释 妊娠晚期感染患者的孕产妇、胎儿和新生儿结局似乎非常好，这些结局是通过强化、积极的管理实现的，在缺乏更可靠数据的情况下，这可能是最佳实践。这些妊娠期间感染 COVID-19 的患者的临床特征与文献报道的非妊娠成人感染 COVID-19 的临床特征相似。版权所有 (C) 2020 爱思唯尔有限公司。保留所有权利。
Background In December, 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China. The number of affected pregnant women is increasing, but scarce information is available about the clinical features of COVID-19 in pregnancy. This study aimed to clarify the clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19.Methods In this retrospective, single-centre study, we included all pregnant women with COVID-19 who were admitted to Tongji Hospital in Wuhan, China. Clinical features, treatments, and maternal and fetal outcomes were assessed.Findings Seven patients, admitted to Tongji Hospital from Jan 1, to Feb 8, 2020, were included in our study. The mean age of the patients was 32 years (range 29-34 years) and the mean gestational age was 39 weeks plus 1 day (range 37 weeks to 41 weeks plus 2 days). Clinical manifestations were fever (six [86%] patients), cough (one [14%] patient), shortness of breath (one [14%] patient), and diarrhoea (one [14%] patient). All the patients had caesarean section within 3 days of clinical presentation with an average gestational age of 39 weeks plus 2 days. The final date of followup was Feb 12, 2020. The outcomes of the pregnant women and neonates were good. Three neonates were tested for SARS-CoV-2 and one neonate was infected with SARS-CoV-2 36 h after birth.Interpretation The maternal, fetal, and neonatal outcomes of patients who were infected in late pregnancy appeared very good, and these outcomes were achieved with intensive, active management that might be the best practice in the absence of more robust data. The clinical characteristics of these patients with COVID-19 during pregnancy were similar to those of non-pregnant adults with COVID-19 that have been reported in the literature. Copyright (C) 2020 Elsevier Ltd. All rights reserved.