In vitro activity of the essential oil of Cinnamomum zeylanicum and eugenol in peroxynitrite-induced oxidative processes
In vitro activity of the essential oil of Cinnamomum zeylanicum and eugenol in peroxynitrite-induced oxidative processes
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DOI：
10.1021/jf050183e
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发表时间：
2005-06-15
影响因子：
6.1
通讯作者：
Morelli, I
中科院分区：
文献类型：
--
作者：
Chericoni, S;Prieto, JA;Morelli, I
以桂科（Cinnamomum zeylanicum Blume）树皮中提取的精油及其三种主要成分丁香酚（eugenol）、(E)-肉桂醛（cinnamaldehyde）和芳樟醇（linalool）（占总成分的82.5%）进行过氧亚硝酸盐诱导硝化和脂质过氧化两种体外模型的实验研究。挥发油和丁香酚的IC50分别为18.4 μ g/mL和46.7 μ M（参比化合物抗坏血酸分别为71.3 μ g/mL和405.0 μ M），抑制过氧亚硝酸盐诱导的脂质过氧化作用的IC50分别为2.0 μ g/mL和13.1 μ M，而参比化合物Trolox的IC50分别为59.0 μ g/mL （235.5 μ M）。相反，(E)-肉桂醛和芳樟醇完全失活。
The essential oil obtained from the bark of Cinnamomum zeylanicum Blume (Lauraceae) and three of its main components, eugenol, (E)-cinnamaldehyde, and linalool (representing 82.5% of the total composition), were tested in two in vitro models of peroxynitrite-induced nitration and lipid peroxidation. The essential oil and eugenol showed very powerful activities, decreasing 3-nitrotyrosine formation with IC50 values of 18.4,mu g/mL and 46.7,mu M, respectively (reference compound, ascorbic acid, 71.3,mu g/mL and 405.0,mu M) and also inhibiting the peroxynitrite-induced lipid peroxidation showing an IC50 of 2.0,mu g/mL and 13.1 mu M, respectively, against 59.0,mu g/mL (235.5,mu M) of the reference compound Trolox. On the contrary, (E)-cinnamaldehyde and linalool were completely inactive.