Release of soluble receptors for tumor necrosis factor in clinical sepsis and experimental endotoxemia.
Release of soluble receptors for tumor necrosis factor in clinical sepsis and experimental endotoxemia.
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临床脓毒症和实验性内毒素血症中肿瘤坏死因子可溶性受体的释放。
DOI：
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发表时间：
1993
影响因子：
6.4
通讯作者：
S. Deventer
中科院分区：
文献类型：
--
作者：
T. Poll;J. Jansen;Diana van Leenen;Marijke von der Mohlen;M. Levi;H. Cate;H. Gallati;J. Cate;S. Deventer
为了评估肿瘤坏死因子（TNF）在可溶性TNF受体（sTNFRs）出现中的作用，研究了20例临床诊断为脓毒症的连续患者，以及7只黑猩猩在给予内毒素（4 ng/kg）（含或不含戊茶碱）后的情况。与健康对照组相比，患者血清sTNFR-p55和sTNFR-p75水平显著升高（两种受体均P <0.0001）。两种可溶性受体的水平与同时测量的免疫反应性TNF浓度相关（p55：r = 0.63，P <0.01; p75：r = 0.69，P <0.001）。在黑猩猩中，内毒素诱导随后的血清TNF和sTNFRs浓度升高。尽管喷替福林将TNF对静脉内毒素的反应降低至20%（P <0.05），但sTNFR的出现仅受到中度抑制（sTNFR-p55平均降低至79%，P <0.05; sTNFR-p75平均降低至77%，P = 0.12）。这些结果表明，TNF或者在全身感染中sTNFR的出现中不起重要作用，或者在一些细菌攻击后少量TNF残留在循环中足以保持其可溶性受体的分泌。
To assess the role of tumor necrosis factor (TNF) in the appearance of soluble TNF receptors (sTNFRs), 20 consecutive patients with a clinical diagnosis of sepsis were studied as were 7 chimpanzees after administration of endotoxin (4 ng/kg) with or without pentoxifylline. The patients had markedly elevated serum levels of sTNFR-p55 and sTNFR-p75 compared with healthy controls (P < .0001 for both receptors). The levels of both soluble receptors correlated with simultaneously measured immunoreactive TNF concentrations (p55: r = .63, P < .01; p75: r = .69, P < .001). In the chimpanzees, endotoxin induced subsequent rises in the serum concentrations of TNF and sTNFRs. Although pentoxifylline reduced the TNF response to intravenous endotoxin to 20% (P < .05), the appearance of sTNFRs was only moderately inhibited (sTNFR-p55 to 79% on average, P < .05; sTNFR-p75 to 77%, P = .12). These results indicate that TNF either does not play an important role in the appearance of sTNFRs in systemic infection or that a small amount of TNF remaining in the circulation after some bacterial challenges is sufficient to preserve the secretion of its soluble receptors.
DOI：
10.1073/pnas.89.11.4845
发表时间：
1992-06-01
影响因子：
11.1
作者：
VANZEE, KJ;KOHNO, T;LOWRY, SF
通讯作者：
LOWRY, SF