Younger children with MS have a distinct CSF inflammatory profile at disease onset
Younger children with MS have a distinct CSF inflammatory profile at disease onset
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DOI：
10.1212/wnl.0b013e3181ce5db0
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发表时间：
2010-02-02
期刊：
影响因子：
9.9
通讯作者：
Waubant, E.
中科院分区：
文献类型：
--
作者：
Chabas, D.;Ness, J.;Waubant, E.
背景资料：早发型和晚发型儿童多发性硬化症（MS）的临床和MRI表现不同，而年龄对CSF炎症特征的影响尚不清楚，可能导致诊断延迟。目的：比较早发型和晚发型儿童MS的CSF细胞和免疫球蛋白G（IgG）特征。方法：我们查询了6个儿童MS中心的数据库，
Background: The clinical and MRI presentation differs between earlier-and later-onset pediatric multiple sclerosis (MS), whereas the effect of age on the CSF inflammatory profile is unknown and may contribute to delayed diagnosis.Objectives: To compare the CSF cellular and immunoglobulin G (IgG) profiles between earlier-and later-onset pediatric MS.Methods: We queried the databases of 6 pediatric MS centers for earlier-onset (onset = 11 and