Time-dependent effects of [apyr]BF4 and key contributors to their mixture stimulation on Vibrio qinghaiensis sp.-Q67 at apical and biochemical levels
Time-dependent effects of [apyr]BF4 and key contributors to their mixture stimulation on Vibrio qinghaiensis sp.-Q67 at apical and biochemical levels
复制标题
[apyr]BF4 及其混合物刺激的关键因素对青海弧菌 sp.-Q67 在顶端和生化水平的时间依赖性影响
DOI：
10.1016/j.jhazmat.2016.03.058
复制
发表时间：
2016-07-15
影响因子：
13.6
通讯作者：
Zhang, Jing
中科院分区：
文献类型：
--
作者：
Yu, ZhenYang;Zhang, Jing
较早的报道研究了咪唑基离子液体（[amim]X）在生化解释方面的时间依赖效应和混合效应的关键贡献者。目前，结合以上两方面研究了n -烷基吡啶基il ([apyr]BF4)，即[bpyr]BF4、[hpyr]BF4和[opyr]BF4对青海弧菌sp.-Q67的发光和生化指标的时间依赖性，以及混合物的影响。在个别结果中，对发光的抑制随浓度和侧链长度的增加而增加，表现出浓度和侧链依赖。[apyr]BF4的抑制作用在0.25 ~ 24h呈下降趋势，具有时间依赖性。值得注意的是，[hpyr]BF4在24 h时刺激了发光，抑制和刺激的生化效应与发光的生化效应密切相关。在混合结果中，对发光的抑制作用低于基于单个结果的浓度加成模型的预测效果。对发光的混合刺激显著高于单个刺激，对生化指标的混合刺激甚至大于对发光的混合刺激。混合效应中，[bpyr]BF4为正贡献者，[hpyr]BF4为负贡献者。[amim]X和[apyr]BF4之间的异同表明了离子液体常见致热效应的潜在机制。(C) 2016年Elsevier B.V.出版
Earlier reports studied the time-dependent effects of imidazolium-based ionic liquids ([amim]X) in the aspect of biochemical explanation and that of key contributor in mixture effects. Presently, the effects of N-alkylpyridinium-based ILs ([apyr]BF4) were studied combining the above two aspects, i.e., the time dependent effects of [bpyr]BF4, [hpyr]BF4 and [opyr]BF4 on luminescence and biochemical indicators in Vibrio qinghaiensis sp.-Q67, and those of the mixtures. In individual results, the inhibition on luminescence increased over concentrations and the side chain length, showing concentration - and side chain-dependence. Moreover, the inhibition of [apyr]BF4 decreased from 0.25 to 24h, showing a time dependence. Notably, [hpyr]BF4 stimulated the luminescence at 24 h. The biochemical effects, including inhibition and stimulation, were well correlated to those on luminescence. In mixture results, the inhibition on luminescence was lower than the predicted effects by concentration addition model which was based on individual results. Moreover, the mixture stimulation on luminescence was significantly higher than individual ones, and the mixture stimulation on biochemical indicators was even greater than that on luminescence. In mixture effects, [bpyr]BF4 was the positive contributor, and [hpyr]BF4 was the negative contributor. Similarities and differences between [amim]X and [apyr]BF4 indicated underlying mechanisms of the commonly observed hormetic effects of ionic liquids. (C) 2016 Published by Elsevier B.V.