Retinal light damage: mechanisms and protection.
Retinal light damage: mechanisms and protection.
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DOI：
10.1016/j.preteyeres.2009.11.004
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发表时间：
2010-03
影响因子：
17.8
通讯作者：
Vaughan, Dana K.
中科院分区：
文献类型：
--
作者：
Organisciak, Daniel T.;Vaughan, Dana K.
关键词：
通过对视紫红质的作用，光触发了众所周知的视觉转导级联，但也可以通过光毒性机制诱导细胞损伤和死亡——尽管经过 40 多年的研究，对这一机制的全面理解仍然难以捉摸。在此，我们整合了最近的实验结果来解决视网膜光损伤的几种假设，部分前提是光感受器和视网膜色素上皮之间密切的解剖和代谢关系。我们首先回顾光损伤的显着特征，最近加入了视网膜重塑的证据，这对视网膜变性功能恢复的预后具有影响。然后，我们考虑影响损伤过程进展和视细胞损失程度的选择因素。讨论了传统的、转基因的和新兴的动物模型，特别强调视锥细胞。探讨了外源性和内源性视网膜保护因子，对光损伤机制的影响以及未来研究的一些建议途径。众所周知，我们的长期光环境与视网膜疾病中的感光细胞死亡之间存在协同作用。了解各种动物模型中光损伤的分子机制可以为光对临床疾病的影响提供有价值的见解，并可能为未来预防或延缓视细胞损失的治疗奠定基础。
By its action on rhodopsin, light triggers the well-known visual transduction cascade, but can also induce cell damage and death through phototoxic mechanisms -- a comprehensive understanding of which is still elusive despite more than 40 years of research. Herein, we integrate recent experimental findings to address several hypotheses of retinal light damage, premised in part on the close anatomical and metabolic relationships between the photoreceptors and the retinal pigment epithelium. We begin by reviewing the salient features of light damage, recently joined by evidence for retinal remodeling which has implications for the prognosis of recovery of function in retinal degenerations. We then consider select factors that influence the progression of the damage process and the extent of visual cell loss. Traditional, genetically-modified, and emerging animal models are discussed, with particular emphasis on cone visual cells. Exogenous and endogenous retinal protective factors are explored, with implications for light damage mechanisms and some suggested avenues for future research. Synergies are known to exist between our long term light environment and photoreceptor cell death in retinal disease. Understanding the molecular mechanisms of light damage in a variety of animal models can provide valuable insights into the effects of light in clinical disorders and may form the basis of future therapies to prevent or delay visual cell loss.
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冻结裂纹证据证明了基底盘的无颗粒斑块以及小鼠和青蛙的视网膜外部片段的质膜中存在胆固醇。
影响因子：
7.8
作者：
Andrews, L D;Cohen, A I
通讯作者：
Cohen, A I
影响因子：
11.4
作者：
André, E;Conquet, F;Becker-André, M
通讯作者：
Becker-André, M
影响因子：
8.3
作者：
Belayev, L;Marcheselli, VL;Bazan, NG
通讯作者：
Bazan, NG
影响因子：
--
作者：
BRESSLER, NM;MUNOZ, B;WEST, SK
通讯作者：
WEST, SK
影响因子：
56.9
作者：
BENOLKEN, RM;ANDERSON, RE;WHEELER, TG
通讯作者：
WHEELER, TG