Plasma complement component 4 increases in patients with major depressive disorder.
Plasma complement component 4 increases in patients with major depressive disorder.
复制标题
重度抑郁症患者血浆补体成分 4 增加
DOI：
10.2147/ndt.s151238
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发表时间：
2018
影响因子：
3.2
通讯作者：
Ma X
中科院分区：
文献类型：
--
作者：
Wei J;Liu Y;Zhao L;Yang X;Ni P;Wang Y;Li T;Ma X
反复观察到严重抑郁障碍(MDD)患者的血浆炎症因子升高，但也有相互矛盾的结果被报道。MDD补体成分的改变也可能通过参与炎症反应参与MDD的病理生理过程。最近发现补体成分4(C4)参与神经突触消除并与精神分裂症相关，提示C4在MDD中可能起作用。本研究对53例MDD患者和60例健康体检者的血浆补体C4和炎症因子IL-1β、IL-6、IL-8、IL-10、干扰素-α、干扰素-γ和肿瘤坏死因子-α进行了检测。同时对51例服用抗抑郁药物的患者中的17例进行血浆分析。结果表明，MDD患者外周血C4水平明显高于正常对照组。未发现炎症因子或补体C4与抑郁或焦虑症状显著相关。抗抑郁药物治疗显著降低MDD患者的血浆C4水平。我们的结果与以往MDD补体成分升高的结果一致，提示C4可能在MDD的病理生理学中起作用，并可能成为MDD生物标志物和病理生理学研究的候选对象。
Elevation of plasma inflammatory factors in major depressive disorder (MDD) has been repeatedly observed, but contradictory results have also been reported. Alteration of complement components in MDD may also contribute to the pathophysiology of MDD by participating in inflammation. The recent findings that complement component 4 (C4) was involved in neural synapse elimination and associated with schizophrenia implicated the potential roles of C4 in MDD. In this study, we analyzed the plasma concentration of complement C4 and inflammatory factors, including interleukin (IL)-1β, IL-6, IL-8, IL-10, interferon-α, interferon-γ and tumor necrosis factor-α, of 53 patients with MDD and 60 healthy individuals. The plasma of 17 patients out of 51 after antidepressant medication was also collected for analysis. The results showed that peripheral C4 in MDD was higher than that in healthy controls. No significant correlation of inflammatory factors or C4 with depressive or anxiety symptoms was found. Antidepressant medication significantly reduced plasma C4 of patients with MDD. Our results were consistent with previous findings that complement components were elevated in MDD and suggested that C4 might play a role in pathophysiology of MDD and could be a candidate in the research of biomarker and the pathophysiology of MDD.