Cortical and trabecular morphology is altered in the limb bones of mice artificially selected for faster skeletal growth.
Cortical and trabecular morphology is altered in the limb bones of mice artificially selected for faster skeletal growth.
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DOI：
10.1038/s41598-017-10317-x
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发表时间：
2017-09-05
影响因子：
4.6
通讯作者：
Rolian C
中科院分区：
文献类型：
--
作者：
Farooq S;Leussink S;Sparrow LM;Marchini M;Britz HM;Manske SL;Rolian C
骨强度受矿物质密度、宏观和微观结构的影响。对影响骨骼形态和强度的因素的研究主要集中在遗传、环境和形态因素(如体重指数)上，但对骨骼延长率对成人骨骼形态和强度的影响知之甚少。使用Micro-CT，我们检测了骨骼延长率对骨皮质和骨小梁形态的影响，以及对CD-1小鼠和骨骼加速生长(Longshanks)小鼠胫骨中雌激素依赖性骨丢失率的影响。成年小鼠每组(n = 7只)行卵巢摘除或假手术，扫描6周，收集骨形态指标。结果表明，在骨骼成熟时，Longshanks小鼠的骨小梁明显减少，其特征是骨小梁更少、更薄，而且对卵巢切除的反应更慢。因此，相对于躯体生长而言，对骨骼快速生长的人工选择对龙腿的骨小梁形态有显着影响。我们的数据并没有明确地证明骨快速生长和骨小梁质量降低之间的因果关系，但提示快速的线性骨生长可能影响松质骨脆性的风险。
Bone strength is influenced by mineral density and macro- and microstructure. Research into factors that contribute to bone morphology and strength has focused on genetic, environmental and morphological factors (e.g., body mass index), but little is known regarding the impact of rates of skeletal elongation on adult skeletal morphology and strength. Using micro-CT, we examined the impact of rates of skeletal elongation on bone cortical and trabecular morphology, and on rates of estrogen-dependent bone loss in the tibia in CD-1 mice, and in mice with accelerated skeletal growth (Longshanks). Groups of adult mice (n = 7/group) were subjected to ovariectomy or sham surgeries, scanned for 6 weeks, and indices of bone morphology were collected. Results show that Longshanks mice had significantly less trabecular bone at skeletal maturity, characterized by fewer, thinner trabeculae, and furthermore lost trabecular bone more slowly in response to ovariectomy. Artificial selection for rapid skeletal growth relative to somatic growth thus had a significant impact on trabecular bone morphology in Longshanks. Our data do not unequivocally demonstrate a causal relationship between rapid bone growth and reduced trabecular bone quality, but suggest that rapid linear bone growth may influence the risk of cancellous bone fragility.
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影响因子：
3.5
作者：
Asomaning, Kofi;Bertone-Johnson, Elizabeth R.;Pekow, Penelope S.
通讯作者：
Pekow, Penelope S.
影响因子：
2.4
作者：
Britz, Hayley M.;Jokihaara, Jarkko;Cooper, David M. L.
通讯作者：
Cooper, David M. L.
影响因子：
4.1
作者：
Cheng, X.;Li, J.;Lang, T.
通讯作者：
Lang, T.
影响因子：
4
作者：
De Laet, C;Kanis, JA;Tenenhouse, A
通讯作者：
Tenenhouse, A
影响因子：
6.2
作者：
Borah, B;Dufresne, TE;Phipps, RJ
通讯作者：
Phipps, RJ