Vascular endothelial growth factor-induced endothelial cell migration and proliferation depend on a nitric oxide-mediated decrease in protein kinase Cδ activity
Vascular endothelial growth factor-induced endothelial cell migration and proliferation depend on a nitric oxide-mediated decrease in protein kinase Cδ activity
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DOI：
10.1161/01.res.85.3.247
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发表时间：
1999-08-06
影响因子：
20.1
通讯作者：
Ware, JA
中科院分区：
文献类型：
--
作者：
Shizukuda, Y;Tang, SQ;Ware, JA
血管内皮生长因子(VEGF)通过影响细胞内介质促进血管生成和内皮细胞(EC)的迁移和增殖，其中只有一部分是已知的，在其受体的远端，蛋白激酶C(PKC)参与了VEGF的功能，但单个PKC同工酶的作用尚不清楚。在这项研究中，我们测试了特定的PKC同工酶活性在人血管内皮细胞迁移和增殖反应中的重要性。直接加入血管内皮细胞生长因子后，PKC-β比活性降低41+/-8%[P
Vascular endothelial growth factor (VEGF) promotes angiogenesis and endothelial cell (EC) migration and proliferation by affecting intracellular mediators, only some of which are known, distal to its receptors, Protein kinase C (PKC) participates in the function of VEGF, but the role of individual PKC isoenzymes is unknown. In this study, we tested the importance of the activity of specific PKC isoenzymes in human EC migration and proliferation in response to VEGF. PKC delta specific activity was depressed by dir addition of VEGF (by 41 +/- 8% [P