A CONTROLLED RETROSPECTIVE STUDY OF GANCICLOVIR TREATMENT FOR CYTOMEGALO-VIRUS RETINOPATHY - USE OF A STANDARDIZED SYSTEM FOR THE ASSESSMENT OF DISEASE OUTCOME
A CONTROLLED RETROSPECTIVE STUDY OF GANCICLOVIR TREATMENT FOR CYTOMEGALO-VIRUS RETINOPATHY - USE OF A STANDARDIZED SYSTEM FOR THE ASSESSMENT OF DISEASE OUTCOME
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DOI：
10.1001/archopht.1989.01070020841024
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发表时间：
1989-12-01
影响因子：
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通讯作者：
KAPLAN, HJ
中科院分区：
文献类型：
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作者：
HOLLAND, GN;BUHLES, WC;KAPLAN, HJ
为了更准确地评估更昔洛韦对巨细胞病毒视网膜病变的临床反应，开发了一种评估疾病结局的系统，该系统使用视网膜照片和三个因素：新病变的发展、原有病变的扩大和病变边界视网膜混浊的变化。使用该系统对24例更昔洛韦治疗的巨细胞病毒视网膜病变患者和17例未治疗的巨细胞病毒视网膜病变患者进行了回顾性比较。一项设盲评估显示，10例接受治疗的患者（43%）在中位22天内发生疾病进展。相比之下，16名未经治疗的患者（94%）在中位25天内出现疾病进展。治疗和未治疗眼睛的比较也表明，治疗可以防止视力在同一时期的恶化。这项研究支持了先前非对照研究的结论，即更昔洛韦对治疗获得性免疫缺陷综合征和巨细胞病毒视网膜病变患者有益。它还表明了所提出的系统的效用，用于评估疾病的结果，可用于治疗坏死性病毒性视网膜病变的未来研究。
To evaluate more accurately the clinical response of cytomegalovirus retinopathy to ganciclovir, a system for the assessment of disease outcome was developed that uses retinal photographs and three factors: development of new lesions, enlargement of preexisting lesions, and change in retinal opacification of lesion borders. With this system a retrospective comparison was performed of 24 ganciclovir-treated patients and 17 untreated patients with cytomegalovirus retinopathy. A masked assessment showed disease progression in 10 treated patients (43%) during a median period of 22 days. In contrast, 16 untreated patients (94%) had progression of disease during a median period of 25 days. Comparison of treated and untreated eyes also suggests that treatment may prevent deterioration of visual acuity during the same period. This study supports the conclusions of previous uncontrolled studies that ganciclovir is beneficial in the treatment of patients with acquired immunodeficiency syndrome and cytomegalovirus retinopathy. It also demonstrates the utility of the proposed system for assessment of disease outcome that can be used in future studies of therapy for necrotizing viral retinopathies.