Contribution of the brain-derived neurotrophic factor and neurometabolites to the motor performance
Contribution of the brain-derived neurotrophic factor and neurometabolites to the motor performance
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脑源性神经营养因子和神经代谢物对运动表现的贡献
DOI：
10.1016/j.bbr.2021.113433
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发表时间：
2021
影响因子：
2.7
通讯作者：
Onishi Hideaki
中科院分区：
文献类型：
--
作者：
Sasaki Ryoki;Watanabe Hiraku;Miyaguchi Shota;Otsuru Naofumi;Ohno Ken;Sakurai Noriko;Kodama Naoki;Onishi Hideaki
个体运动能力受多种因素的影响。虽然关键因素尚未完全阐明，但脑源性神经营养因子（BDNF）基因型以及神经代谢物可能成为取决于学习阶段的贡献因素。我们研究了BDNF基因的Met等位基因和神经代谢物对视觉学习的影响。总共有43名健康参与者使用右手食指进行了由10个区块组成的视觉学习任务（Val 66 Val，n= 15; Val 66 Met，n= 15;和Met 66 Met，n= 13）。谷氨酸加谷氨酰胺（Glx）的浓度在初级运动皮层，初级躯体感觉皮层（S1），小脑进行了评估，使用3-T磁共振波谱在19名参与者参加了视觉学习任务。对于学习阶段，任务误差（即，与在其余组中观察到的相比，Met 66 Met组中的学习能力（学习能力）显著更小，与学习阶段无关（所有p值< 0.003）。在Val 66 Val和Met 66 Met组之间观察到学习斜率的显著差异（即，学习速度）在早期学习阶段（p= 0.048），而在晚期学习阶段（p值均> 0.54）。学习斜率与Glx浓度仅在学习早期（r= 0.579，p = 0.009）呈显著正相关（r= 0.579，p = 0.009）。S1区BDNF基因型和Glx浓度对早期学习阶段学习速度的个体间差异有部分影响。
Individual motor performance ability is affected by various factors. Although the key factor has not yet completely been elucidated, the brain-derived neurotrophic factor (BDNF) genotype as well as neurometabolites may become contibuting factors depending on the learning stage. We investigated the effects of the Met allele of the BDNF gene and those of the neurometabolites on visuomotor learning. In total, 43 healthy participants performed a visuomotor learning task consisting of 10 blocks using the right index finger (Val66Val,n= 15; Val66Met,n= 15; and Met66Met,n= 13). Glutamate plus glutamine (Glx) concentrations in the primary motor cortex, primary somatosensory cortex (S1), and cerebellum were evaluated using 3-T magnetic resonance spectroscopy in 19 participants who participated in the visuomotor learning task. For the learning stage, the task error (i.e., learning ability) was significantly smaller in the Met66Met group compared with that observed in the remaining groups, irrespective of the learning stage (allpvalues < 0.003). A significant difference was observed between the Val66Val and Met66Met groups in the learning slope (i.e., learning speed) in the early learning stage (p= 0.048) but not in the late learning stage (allpvalues> 0.54). Moreover, positive correlations were detected between the learning slope and Glx concentrations in S1 only in the early learning stage (r= 0.579,p= 0.009). The BDNF genotype and Glx concentrations in S1 partially contribute to interindividual variability on learning speed in the early learning stage.