Preexisting subtype immunodominance shapes memory B cell recall response to influenza vaccination
Preexisting subtype immunodominance shapes memory B cell recall response to influenza vaccination
复制标题
DOI：
10.1172/jci.insight.132155
复制
发表时间：
2020-01-16
期刊：
影响因子：
8
通讯作者：
Ross, Ted M.
中科院分区：
文献类型：
--
作者：
Abreu, Rodrigo B.;Kirchenbaum, Greg A.;Ross, Ted M.
流感是一种高度传染性的病毒病原体，在2017-2018赛季期间，美国报告了超过20万例病例。世界卫生组织建议每年接种疫苗，目的是减少流感的严重程度和传播。目前可用的疫苗有效率约为60%，疫苗有效性随季节而变化，以及在一个季节内不同流感亚型之间。来自早期流感感染的免疫印记可以显著地塑造对随后感染的免疫反应。在此，使用流感疫苗接种前和接种后21-28天从健康受试者（18-85岁）采集的血液样本评估了预先存在的B细胞记忆对四价流感疫苗应答的影响。流感疫苗接种增加HA特异性抗体和记忆8细胞频率。尽管疫苗组分之间的抗原性没有明显差异，但大多数人偏向于其中一种疫苗株。具体而言，相对于其他疫苗组分，对H3 N2的反应在幅度上降低。总的来说，这项研究揭示了一种潜在的新机制，这种机制是针对不同流感亚型的差异疫苗有效性的基础。
Influenza is a highly contagious viral pathogen with more than 200,000 cases reported in the United States during the 2017-2018 season. Annual vaccination is recommended by the World Health Organization, with the goal to reduce influenza severity and transmission. Currently available vaccines are about 60% effective, and vaccine effectiveness varies from season to season, as well as between different influenza subtypes within a single season. Immunological imprinting from early-life influenza infection can prominently shape the immune response to subsequent infections. Here, the impact of preexisting B cell memory in the response to quadrivalent influenza vaccine was assessed using blood samples collected from healthy subjects (18-85 years old) prior to and 21-28 days following influenza vaccination. Influenza vaccination increased both HA-specific antibodies and memory 8 cell frequency. Despite no apparent differences in antigenicity between vaccine components, most individuals were biased toward one of the vaccine strains. Specifically, responses to H3N2 were reduced in magnitude relative to the other vaccine components. Overall, this study unveils a potentially new mechanism underlying differential vaccine effectiveness against distinct influenza subtypes.