Ethnic-Specific Normative Reference Values for Echocardiographic LA and LV Size, LV Mass, and Systolic Function The EchoNoRMAL Study
Ethnic-Specific Normative Reference Values for Echocardiographic LA and LV Size, LV Mass, and Systolic Function The EchoNoRMAL Study
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DOI：
10.1016/j.jcmg.2015.02.014
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发表时间：
2015-06-01
影响因子：
14
通讯作者：
Whalley, G. A.
中科院分区：
文献类型：
--
作者：
Aune, E.;Brown, A.;Whalley, G. A.
目的本研究试图从不同地域的人群研究中得出年龄、性别和种族相适应的成人左心房(LA)和左心室(LV)内径和容量、左心室质量、短轴缩短率和射血分数(EF)的参考值。背景目前超声心动图测量的推荐参考值可能不适用于目前应用这些参考值的世界不同人群。采用分位数回归的方法，分别在性别和民族间计算各指标对年龄的95百分位数(上参考值[URV]和第5百分位数(下参考值[LRV])的参考值。结果欧洲人的左心室舒张末容量(LVEDV)、左心室收缩末期容量(LV)和左每搏输出量(SV)的URV在欧洲人最高，南亚人最低。在按体表面积或身高指数化后，这些测量以及SV的LRV仍然存在重要的性别和种族差异。各年龄组的LVEDV和SV均随年龄增长而减小。重要的是，EF的LRV因种族而异；欧洲人和亚洲人之间有明显的差异。欧洲人的左心室舒张末内径和左心室收缩末期内径的URV高于东亚、南亚和非洲人，尤其是男性。同样，欧洲人的左房直径和容量的URV最高。结论许多测量左房和左室大小、左室质量和EF的超声心动图参考值是性别和/或种族相适应的。不同年龄段的LV体积和质量的参考值也不同。(J Am Coll心脏ol IMG 2015；8：656-65)(C)2015由美国心脏病学会基金会主办。
OBJECTIVES This study sought to derive age-, sex-, and ethnic-appropriate adult reference values for Left atrial (LA) and Left ventricular (LV) dimensions and volumes, LV mass, fractional shortening, and ejection fraction (EF) derived from geographically diverse population studies..BACKGROUND The current recommended reference values for measurements from echocardiography may not be suitable to the diverse world population to which they are now applied.METHODS Population-based datasets of echocardiographic measurements from 22,404 adults without clinical cardiovascular or renal disease, hypertension, or diabetes were combined in an individual person data meta-analysis. Quantile regression was used to derive reference values at the 95th percentile (upper reference value [URV] and fifth percentile (lower reference value [LRV]) of each measurement against age (treated as Linear), separately within sex and ethnic groups.RESULTS The URVs for Left ventricular end-diastolic volume (LVEDV), LV end-systolic volume, and LV stroke volume (SV) were highest in Europeans and lowest in South Asians. Important sex and ethnic differences remained after indexation by body surface area or height for these measurements, as well as for the LRV for SV. LVEDV and SV decreased with increasing age for all groups. Importantly, the LRV for EF differed by ethnicity; there was a clear apparent difference between Europeans and Asians. The URVs for LV end-diastolic diameter and LV end-systolic diameter were higher for Europeans than those for East Asian, South Asian, and African people, particularly among men. Similarly, the URVs for LA diameter and volume were highest for Europeans.CONCLUSIONS Sex- and/or ethnic-appropriate echocardiographic reference values are indicated for many measurements of LA and LV size, LV mass, and EF. Reference values for LV volumes and mass also differ across the age range. (J Am Coll Cardiol Img 2015;8:656-65) (C) 2015 by the American College of Cardiology Foundation.