Metabolic consequences of sleep and circadian disorders.
Metabolic consequences of sleep and circadian disorders.
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DOI：
10.1007/s11892-014-0507-z
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发表时间：
2014-07
影响因子：
4.2
通讯作者：
Wright KP Jr
中科院分区：
文献类型：
--
作者：
Depner CM;Stothard ER;Wright KP Jr
睡眠和昼夜节律调节或控制日常生理模式，对正常代谢健康具有重要意义。与睡眠时间表不足相关的睡眠不足、睡眠时间短的失眠、睡眠呼吸暂停、发作性睡病、昼夜节律失调、轮班工作、夜间进食综合征和睡眠相关的进食障碍都可能导致代谢失调。与代谢失调相关的睡眠不足和昼夜节律紊乱可能通过改变食物摄入的时间和数量、破坏能量平衡、炎症、损害葡萄糖耐量和胰岛素敏感性而导致体重增加、肥胖和2型糖尿病。鉴于代谢性疾病的发病率迅速增加，认识到睡眠和昼夜节律紊乱在代谢性疾病的发生、进展和发病中的作用是很重要的。一些研究结果表明，睡眠治疗和对策可以改善代谢健康，但需要进一步的临床研究，通过治疗睡眠和昼夜节律紊乱来预防和治疗慢性代谢紊乱。
Sleep and circadian rhythms modulate or control daily physiological patterns with importance for normal metabolic health. Sleep deficiencies associated with insufficient sleep schedules, insomnia with short-sleep duration, sleep apnea, narcolepsy, circadian misalignment, shift work, night eating syndrome and sleep-related eating disorder may all contribute to metabolic dysregulation. Sleep deficiencies and circadian disruption associated with metabolic dysregulation may contribute to weight gain, obesity, and type 2 diabetes potentially by altering timing and amount of food intake, disrupting energy balance, inflammation, impairing glucose tolerance and insulin sensitivity. Given the rapidly increasing prevalence of metabolic diseases, it is important to recognize the role of sleep and circadian disruption in the development, progression, and morbidity of metabolic disease. Some findings indicate sleep treatments and countermeasures improve metabolic health, but future clinical research investigating prevention and treatment of chronic metabolic disorders through treatment of sleep and circadian disruption is needed.