In vivo burn depth determination by high-speed fiber-based polarization sensitive optical coherence tomography
In vivo burn depth determination by high-speed fiber-based polarization sensitive optical coherence tomography
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DOI：
10.1117/1.1413208
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发表时间：
2001-10-01
影响因子：
3.5
通讯作者：
de Boer, JF
中科院分区：
文献类型：
--
作者：
Park, BH;Saxer, C;de Boer, JF
我们报告了基于高速光纤的偏振敏感光学相干断层扫描（PS-OCT）的首次应用，对体内烧伤组织进行成像。热损伤会使皮肤中的胶原蛋白变性，PS-OCT 可以利用在组织中传播和反射的光的偏振状态的深度分辨变化来测量胶原蛋白双折射的减少。计算扫描中每个点的斯托克斯矢量，并计算相对于使用四种入射偏振态确定的入射偏振的双折射。使用基于高速光纤的 PS-OCT 系统对不同时间烧伤的大鼠皮肤进行分析，建立双折射与组织学分析确定的实际烧伤深度之间的相关性。总之，PS-OCT 在无创评估烧伤深度方面具有潜在用途。 (C) 2001 年光电仪器工程师学会。
We report the first application of high-speed fiber-based polarization sensitive optical coherence tomography (PS-OCT) to image burned tissue in vivo. Thermal injury denatures collagen in skin and PS-OCT can measure the reduction in collagen birefringence using depth resolved changes in the polarization state of light propagated in, and reflected from, the tissue. Stokes vectors were calculated for each point in a scan and birefringence relative to incident polarization determined using four incident polarization states. Using a high-speed fiber-based PS-OCT system on rat skin burned for varying periods of time, a correlation between birefringence and actual burn depth determined by histological analysis was established. In conclusion, PS-OCT has potential use for noninvasive assessment of burn depth. (C) 2001 Society of Photo-Optical Instrumentation Engineers.