Applications of diffusion tensor MR imaging in multiple sclerosis
Applications of diffusion tensor MR imaging in multiple sclerosis
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DOI：
10.1196/annals.1340.039
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Grossman, RI
中科院分区：
文献类型：
--
作者：
Ge, YL;Law, M;Grossman, RI
多发性硬化症（MS）是一种中枢神经系统的炎性脱髓鞘疾病，是美国年轻人非创伤性残疾的最常见原因。近年来，磁共振成像（MRI）已被确立为MS临床诊断、自然病程和治疗效果评估的重要临床旁工具。在MS研究中，具有灵敏可靠的体内方法用于研究疾病过程中白色物质的特定病理变化及其完整性具有许多优点。因此，在过去的十年中，MRI在MS研究中的应用已经从传统的MRI探索到具有更高病理特异性和灵敏度的新的先进定量技术。扩散张量成像（DTI）是MS最有前途的技术之一。它量化了组织内非随机水扩散的量，并提供了有关脑微结构损伤导致的影响水扩散的病理过程的独特体内信息。本文概述了DTI和纤维追踪成像在MS疾病研究中的现状和未来方向。
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system that is the most common cause of nontraumatic disability in young adults in the United States. In recent years, magnetic resonance imaging (MRI) has been established as an important paraclinical tool in MS for the assessment of clinical diagnosis, natural history, and treatment effects. In MS studies, there are many advantages to having a sensitive and reliable in vivo method for investigating the specific pathological changes of white matter and its integrity during the disease process. As a consequence, in the past decade, the application of MRI to the study of MS has been explored from conventional MRI to new advanced quantitative techniques with greater pathological specificity and sensitivity. Diffusion tensor imaging (DTI) is one of the most promising techniques with regard to MS. It quantities the amount of nonrandom water diffusion within tissues and provides unique in vivo information about the pathological processes that affect water diffusion as a result of brain microstructural damage. This review outlines the current state of the art and future direction of DTI and fiber tractography in the study of MS disease.