Lung cancer in patients with HIV infection: is it AIDS-related?
Lung cancer in patients with HIV infection: is it AIDS-related?
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DOI：
10.1111/j.1468-1293.2004.00196.x
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发表时间：
2004-03-01
期刊：
影响因子：
3
通讯作者：
Yust, I
中科院分区：
文献类型：
--
作者：
Burke, M;Furman, A;Yust, I
艾滋病毒感染者患恶性肿瘤的风险增加，尤其是非霍奇金淋巴瘤和卡波西肉瘤。最近，一些工作人员注意到艾滋病毒阳性受试者的肺癌患病率有所上升。我们描述了四名患有肺癌的艾滋病毒血清阳性患者的诊断和临床病程。所有患者都很年轻并且是重度吸烟者。他们都接受高效抗逆转录病毒治疗（HAART），尽管依从性从差到极好。这些患者的 CD4 细胞计数范围为 200 至 686 个细胞/μL，病毒载量范围为不可检测到 29 000 个 HIV-1 RNA 拷贝/mL。在5至13年前首次诊断出HIV感染后，他们都出现了晚期肺癌，临床病程非常短，四人均在诊断后2-9个月内死亡。我们中心艾滋病毒感染者的肺癌发病率与一般人群的比较表明，艾滋病毒感染者的肺癌患病率有所增加。我们回顾了文献并讨论了HIV感染引起的肺癌是巧合还是与原发病有关。
HIV-infected individuals have an increased risk of malignancy, especially non-Hodgkin's lymphoma and Kaposi's sarcoma. Recently, several workers have noted a raised prevalence of lung cancer in HIV-positive subjects. We describe the diagnosis and clinical course for four HIV-seropositive patients who presented with lung cancer. All of the patients were young and were heavy smokers. They were all on highly active antiretroviral therapy (HAART), although the adherence varied from poor to excellent. The CD4 cell counts of these patients ranged from 200 to 686 cells/muL and their viral loads ranged from undetectable to 29 000 HIV-1 RNA copies/mL. After initial diagnosis of HIV infection between 5 and 13 years previously, they all presented with advanced lung cancer, with a very short clinical course, and all four died within 2-9 months of diagnosis. A comparison of the incidence of lung cancer in patients with HIV infection at our centre with that in the general population suggests that there is an increased prevalence in the HIV-infected patients. We review the literature and discuss whether lung cancer in HIV infection is coincidental or related to the primary disease.