Precise development of functional and anatomical columns in the neocortex
Precise development of functional and anatomical columns in the neocortex
复制标题
DOI：
10.1016/j.neuron.2004.05.002
复制
发表时间：
2004-06-10
期刊：
影响因子：
16.2
通讯作者：
Svoboda, K
中科院分区：
文献类型：
--
作者：
Bureau, I;Shepherd, GMG;Svoboda, K
感觉皮层被排列成列，每个列都适应周围刺激的一个子集。为了确定柱状结构构建的原理，我们使用突触连接的激光扫描光刺激分析、轴突乔木的重建和体内全细胞记录来监测大鼠桶状皮层中电路的发育。从第 4 层和第 2/3 层撞击到第 2/3 层神经元的电路以单调、精确的进展方式发展，几乎没有证据表明皮层柱水平存在短暂的过度神经支配。与此一致的是，在 PND 8 时，在这些神经元停止迁移后，在 2/3 层神经元中测量的突触电流显示出已经在空间上调整良好的感受野。
Sensory cortex is ordered into columns, each tuned to a subset of peripheral stimuli. To identify the principles underlying the construction of columnar architecture, we monitored the development of circuits in the rat barrel cortex, using laser-scanning photostimulation analysis of synaptic connectivity, reconstructions of axonal arbors, and in vivo whole-cell recording. Circuits impinging onto layer 2/3 neurons from layers 4 and 2/3 developed in a monotonic, precise progression, with little evidence for transient hyperinnervation at the level of cortical columns. Consistent with this, synaptic currents measured in layer 2/3 neurons at PND 8, just after these neurons ceased to migrate, revealed already spatially well-tuned receptive fields.