NEUROFIBRILLARY TANGLES IN DEMENTIA-PUGILISTICA ARE UBIQUITINATED
NEUROFIBRILLARY TANGLES IN DEMENTIA-PUGILISTICA ARE UBIQUITINATED
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DOI：
10.1136/jnnp.54.2.116
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发表时间：
1991-02-01
影响因子：
11
通讯作者：
ROBERTS, GW
中科院分区：
文献类型：
--
作者：
DALE, GE;LEIGH, PN;ROBERTS, GW
泛素，一种被认为参与异常蛋白的ATP依赖性非溶酶体降解的蛋白质，已经被鉴定为阿尔茨海默病中神经元缠结的组分。我们已经研究了泛素免疫反应性的独特的收集大脑从16个前拳击手，包括11个痴呆拳击手。拳击员痴呆的神经纤维缠结用亲和纯化的抗血清标记泛素，和BF 10，一种单克隆抗体的神经丝表位。
Ubiquitin, a protein thought to be involved in the ATP-dependent nonlysosomal degradation of abnormal proteins, has already been identified as a component of neurofibrillary tangles in Alzheimer's disease. We have examined ubiquitin immunoreactivity in a unique collection of brains from 16 ex-boxers including 11 with dementia pugilistica. Neurofibrillary tangles of dementia pugilistica were labelled with an affinity purified antiserum to ubiquitin, and BF10, a monoclonal antibody to a neurofilament epitope.