Apple pectin and a polyphenol-rich apple concentrate are more effective together than separately on cecal fermentations and plasma lipids in rats
Apple pectin and a polyphenol-rich apple concentrate are more effective together than separately on cecal fermentations and plasma lipids in rats
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DOI：
10.1093/jn/133.6.1860
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发表时间：
2003-06-01
影响因子：
4.2
通讯作者：
Demigné, C
中科院分区：
文献类型：
--
作者：
Aprikian, O;Duclos, V;Demigné, C
为了评估苹果成分对盲肠发酵和脂质代谢的影响，给大鼠喂食含有5 g/100 g苹果果胶（PEC）、10 g/100 g高多酚冻干苹果（PL）或两者（PEC + PL）的饮食。仅饲喂 PEC + PL 饮食的大鼠的盲肠 pH 值呈弱酸性（6.49）（对照组为 7.02）。所有苹果组分都扩大了盲肠短链脂肪酸库，喂食 PEC + PL 饮食的大鼠的峰值为 560 mumol，而对照组的峰值为 189 mumol。喂食 PL 饮食的大鼠中的丁酸盐浓度是对照组大鼠的 2 倍。在喂食 PEC 饮食的大鼠的盲肠中发现了高浓度的半乳糖醛酸和琥珀酸（大约 40 mmol/L），而喂食 PEC + PL 饮食的大鼠的盲肠中发现了较高浓度的半乳糖醛酸和琥珀酸。 PEC + PL 饮食显着降低血浆胆固醇，而 PL 和 PEC + PL 饮食均降低血浆甘油三酯。饲喂 PEC 和 PEC + PL 饮食的大鼠肝脏胆固醇和甘油三酯浓度较低。膳食PEC可显着减少粪便胆汁酸排泄，而甾醇排泄显着增加。饲喂 PEC 和 PEC + PL 饮食的大鼠的表观胆固醇吸收率也低于对照组（分别为 30% 和 43%）。总之，苹果果胶和富含多酚的部分在联合喂养时比单独喂养时对大肠发酵和脂质代谢更有效，这表明苹果纤维和多酚之间存在相互作用。 J.努特尔。 133：1860-1865，2003 年。
To evaluate the effect of apple components on cecal fermentations and lipid metabolism, rats were fed diets containing 5 g/100 g apple pectin (PEC), 10 g/100 g high polyphenol freeze-dried apple (PL) or both (PEC + PL). The cecal pH was slightly acidic (6.49) only in rats fed the PEC + PL diet (controls, 7.02). The cecal short-chain fatty acid pool was enlarged by all the apple fractions, with a peak of 560 mumol in rats fed the PEC + PL diet compared with 189 mumol in controls. Butyrate concentrations were 2-fold greater in rats fed the PL diet than in controls. Substantial concentrations of galacturonate and succinate (approximate to40 mmol/L) were found in the cecum of rats fed the PEC diet and, to a lesser extent, the PEC + PL diet. The PEC + PL diet significantly lowered plasma cholesterol, whereas both the PL and PEC + PL diets lowered plasma triglycerides. Liver cholesterol and triglyceride concentrations were lower in rats fed the PEC and PEC + PL diets. Fecal bile acid excretion was markedly reduced, whereas sterol excretion was significantly increased by dietary PEC. Rats fed the PEC and PEC + PL diets also had lower apparent cholesterol absorption than controls (30 compared with 43%). In conclusion, apple pectin and the polyphenol-rich fraction were more effective when fed combined together than when fed separately on large intestine fermentations and lipid metabolism, suggesting interactions between fibers and polyphenols of apple. J. Nutr. 133: 1860-1865, 2003.