Declaring a tuberculosis outbreak over with genomic epidemiology
Declaring a tuberculosis outbreak over with genomic epidemiology
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DOI：
10.1099/mgen.0.000060
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发表时间：
2016-05-01
影响因子：
3.9
通讯作者：
Gardy, Jennifer L.
中科院分区：
文献类型：
--
作者：
Hatherell, Hollie-Ann;Didelot, Xavier;Gardy, Jennifer L.
我们报告了一种更新的方法，用于根据时间标记的病原体基因组系统发育来推断传染病在人与人之间传播的时间。作为实时公共卫生暴发调查的一部分，我们将该方法应用于 48 个结核分枝杆菌基因组，结果表明，尽管 2013 年诊断出活动性结核病 (TB) 病例，但 2012 年中期之后没有发生传播事件。随后的病例是从潜伏结核感染进展为活动性疾病的结果，而不是最近的传播。这种进化基因组方法被用来宣布 2015 年 1 月的疫情结束。
We report an updated method for inferring the time at which an infectious disease was transmitted between persons from a time-labelled pathogen genome phylogeny. We applied the method to 48 Mycobacterium tuberculosis genomes as part of a real-time public health outbreak investigation, demonstrating that although active tuberculosis (TB) cases were diagnosed through 2013, no transmission events took place beyond mid-2012. Subsequent cases were the result of progression from latent TB infection to active disease, and not recent transmission. This evolutionary genomic approach was used to declare the outbreak over in January 2015.