A perspective on murine keratinocyte stem cells as targets of chemically induced skin cancer
A perspective on murine keratinocyte stem cells as targets of chemically induced skin cancer
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DOI：
10.1002/mc.20355
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发表时间：
2007-08-01
影响因子：
4.6
通讯作者：
Morris, Rebecca J.
中科院分区：
文献类型：
--
作者：
Kangsamaksin, Thaned;Park, Heui Joon;Morris, Rebecca J.
虽然关于癌症的干细胞起源的观点可以追溯到一百多年前，但支持这些理论的关键证据在很大程度上缺乏。我们的目的是概述我们对皮肤上皮中角质细胞干细胞的历史观点，并总结表明上皮干细胞可能有助于化学诱导皮肤癌的具体证据。我们注意到，虽然强有力的证据确实支持这一假设，但正在进行的实验可能提供来自毛囊干细胞的肿瘤的直接可视化。(c) 2007 Wiley-Liss, Inc。
Although ideas on the stem cell origins of cancer date more than one hundred years, critical evidence to support these theories is largely lacking. Our objective here is to outline our historical perspective on keratinocyte stem cells in the cutaneous epithelium and to summarize specific evidence suggesting that epithelial stem cells may contribute to chemically induced skin cancer. We note that, while strong evidence does support this hypothesis, experiments in progress may provide direct visualization of tumors derived from hair follicle stem cells. (c) 2007 Wiley-Liss, Inc.