Higher platelet distribution width is associated with unfavorable prognosis in ovarian cancer
Higher platelet distribution width is associated with unfavorable prognosis in ovarian cancer
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DOI：
10.3233/cbm-191190
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发表时间：
2020-01-01
影响因子：
3.1
通讯作者：
Shen, Wenjie
中科院分区：
文献类型：
--
作者：
Qin, Ling;Li, Jia-Yu;Shen, Wenjie
背景：卵巢癌是妇科恶性肿瘤之一。血小板在肿瘤的生长和转移中起着重要作用。血小板分布宽度（PDW）是血小板活化的指标，并且在恶性肿瘤中改变。然而，PDW在OC中的预后价值仍不清楚。本研究旨在探讨PDW在OC中的预测意义。方法：2013年1月至2013年12月期间，221例OC患者纳入本研究。分析PDW与临床病理特征的相关性。采用Kaplan-Meier法和考克斯回归分析PDW对预后的影响。结果：221例患者中，163例（73.6%）患者PDW水平升高。Kaplan-Meier分析显示，较高的PDW水平与较差的无进展生存期和总生存期相关（均p < 0.001）。Cox回归分析证实PDW对总生存期有独立预测价值（HR = 2.820，95% CI = 1.776-4.476，p < 0.001）。PDW升高可能是治疗的新靶点。
BACKGROUND: Ovarian cancer (OC) is one of the most malignant gynecological cancers. Platelets play a profound role in cancer growth and metastasis. Platelet distribution width (PDW) is an indicator of platelet activation and is altered in malignancies. However, the prognostic value of PDW in OC remains unclear. This present study aimed to investigate the predictive significance of PDW in OC.METHODS: 221 OC patients, between January 2013 and December 2013, were included in this study. The correlations between PDW and clinicopathological features were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of PDW.RESULTS: Of the 221 patients, increased PDW levels were observed in 163 (73.6%) patients. Kaplan-Meier analysis revealed that higher PDW levels were associated with poor progression-free survival and overall survival (both p < 0.001). Cox-regression analysis confirmed the independent predictive value of PDW on overall survival (HR = 2.820, 95% CI = 1.776-4.476, p < 0.001).CONCLUSION: Higher PDW levels predict poor prognosis in patients with OC. Elevated PDW may be a novel target for therapy.