[White Matter Lesion and Alzheimer's Disease: The Association between Small Vessel Disease and Neuropsychiatric Symptoms in Alzheimer's Disease].
[White Matter Lesion and Alzheimer's Disease: The Association between Small Vessel Disease and Neuropsychiatric Symptoms in Alzheimer's Disease].
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DOI：
10.11477/mf.1416200158
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发表时间：
2015-04-01
期刊：
影响因子：
--
通讯作者：
Ikeda, Manabu
中科院分区：
文献类型：
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作者：
Hashimoto, Mamoru;Ikeda, Manabu
脑小血管病（SVD），包括皮质下腔隙性梗死（腔隙）和白色高信号（WMH），是老年人和非老年人MRI上常见的疾病。SVD在阿尔茨海默病（AD）患者中经常观察到。然而，SVD与AD患者表现出的临床症状之间的关联仍不清楚。我们最近的研究表明，AD患者在CT/MRI上观察到的脑SVD与妄想和谵妄以及抑郁有关。AD患者这些精神症状的潜在机制尚不清楚。
Cerebral small vessel disease (SVD), including subcortical lacunar infarcts (lacunes) and white matter hyperintensities (WMH), is commonly observed on MRI of elderly individuals with and without dementia. SVD is frequently observed in patients with Alzheimer's disease (AD). However, the association between SVD and clinical symptoms exhibited by patients with AD remains unclear. Our recent studies suggest that cerebral SVD observed on CT/MRI of patients with AD is associated with delusions and delirium as well as depression. Mechanisms underlying these psychiatric symptoms in patients with AD remain unclear.