The Prevention of Acute Renal Failure in the Rat by Long-Term Saline Loading
The Prevention of Acute Renal Failure in the Rat by Long-Term Saline Loading
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长期盐水负荷预防大鼠急性肾衰竭
DOI：
10.3181/00379727-131-33937
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发表时间：
1969
影响因子：
--
通讯作者：
D. Oken
中科院分区：
文献类型：
--
作者：
F. Mcdonald;G. Thiel;Douglas R. Wilson;G. Dibona;D. Oken
用1%生理盐水代替饮用水在很大程度上阻止了肌肉注射甘油大鼠急性肾功能衰竭的发展。对照实验表明，这种对急性肾功能衰竭的保护不是由于血容量扩大、多尿、多食、低尿渗透压或其他研究参数。这表明，与慢性盐负荷相关的肾素消耗可能发挥了保护作用，肾素-血管紧张素轴可能是甘油诱导的大鼠急性肾功能衰竭的一个重要因素。
Summary Substitution of 1% saline for drinking water largely prevents the development of established acute renal failure in rats given glycerol intramuscularly. Control experiments indicate that this protection from acute renal failure is not due to the blood volume expansion, polyuria, polydypsia, lower urine osmolality, or other parameters studied. It is suggested that the depletion of renin, associated with chronic saline-loading, may have played a protective role, and that the renin-angiotensin axis may be a potent factor in the development of glycerol-induced acute renal failure in the rat.