The effect of beta-alanine supplementation on neuromuscular fatigue in elderly (55-92 Years): a double-blind randomized study
The effect of beta-alanine supplementation on neuromuscular fatigue in elderly (55-92 Years): a double-blind randomized study
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DOI：
10.1186/1550-2783-5-21
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发表时间：
2008-11-07
影响因子：
5.1
通讯作者：
Harris, Roger C.
中科院分区：
文献类型：
--
作者：
Stout, Jeffrey R.;Graves, B. Sue;Harris, Roger C.
背景资料：衰老与骨骼肌肌肽的显著减少有关，这与肌肉缓冲能力的降低有关，并且在理论上可能会增加运动期间的疲劳率。补充β-丙氨酸已显示出显著增加骨骼肌肌肽。因此，本研究的目的是检查90天的β-丙氨酸补充对老年男性和女性在疲劳阈值（PWCFT）时的体力工作能力的影响。方法：采用双盲安慰剂对照设计，26例男性（n = 9）和女性（n = 17）（年龄+/- SD = 72.8 +/- 11.1岁）被随机分配到β-丙氨酸（BA：800 mg × 3/天; n = 12; CarnoSyn（TM））或安慰剂（PL; n = 14）组。在补充期之前（前）和之后（后），参与者进行了不连续的自行车测力计测试以确定PWCFT。结果：BA治疗组的PWCFT从补充前到补充后显着增加（28.6%）（p < 0.05），但PL治疗没有观察到变化。这些研究结果表明，90天的BA补充剂可能会增加身体的工作能力，通过延迟老年男性和女性的神经肌肉疲劳的发作。结论：我们建议，BA补充剂，通过改善细胞内pH值控制，提高肌肉耐力在老年人。我们相信，这对预防福尔斯、维持老年人的健康和独立生活具有重要意义。
Background: Ageing is associated with a significant reduction in skeletal muscle carnosine which has been linked with a reduction in the buffering capacity of muscle and in theory, may increase the rate of fatigue during exercise. Supplementing beta-alanine has been shown to significantly increase skeletal muscle carnosine. The purpose of this study, therefore, was to examine the effects of ninety days of beta-alanine supplementation on the physical working capacity at the fatigue threshold (PWCFT) in elderly men and women.Methods: Using a double-blind placebo controlled design, twenty-six men (n = 9) and women (n = 17) (age +/- SD = 72.8 +/- 11.1 yrs) were randomly assigned to either beta-alanine (BA: 800 mg x 3 per day; n = 12; CarnoSyn (TM)) or Placebo (PL; n = 14) group. Before (pre) and after (post) the supplementation period, participants performed a discontinuous cycle ergometry test to determine the PWCFT.Results: Significant increases in PWCFT (28.6%) from pre- to post-supplementation were found for the BA treatment group (p < 0.05), but no change was observed with PL treatment. These findings suggest that ninety days of BA supplementation may increase physical working capacity by delaying the onset of neuromuscular fatigue in elderly men and women.Conclusion: We suggest that BA supplementation, by improving intracellular pH control, improves muscle endurance in the elderly. This, we believe, could have importance in the prevention of falls, and the maintenance of health and independent living in elderly men and women.