Protective effect and mechanism of mesenchymal stem cells on heat stroke induced intestinal injury
Protective effect and mechanism of mesenchymal stem cells on heat stroke induced intestinal injury
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间充质干细胞对中暑肠道损伤的保护作用及机制
DOI：
10.3892/etm.2020.9051
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发表时间：
2020-07
影响因子：
2.7
通讯作者：
Hongjun Kang
中科院分区：
文献类型：
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作者：
Lu Wang;Zihui Deng;Rui Yuan;Yan Zhao;Mengmeng Yang;Jie Hu;Yu Zhang;Yun Li;Feihu Zhou;Hongjun Kang
中暑(HS)被认为是由高热引起的一种严重的全身性炎症反应疾病。由于缺乏有效的治疗方法，HS的死亡率在世界范围内很高。目前，间充质干细胞(MSCs)已被证明具有炎症和免疫调节作用。因此，本研究旨在探讨MSCs对HS诱导的炎症反应和器官功能障碍的保护作用及其机制。采用高温环境诱导大鼠HS模型，经尾静脉注射MSCs。分别于第1、7、14、28天检测脏器功能分子标志物、炎症因子和趋化因子水平。对大鼠和对照组的肠道进行组织学染色，并比较两组大鼠的Chiu‘s评分。结果表明，骨髓间充质干细胞注射可显著降低小鼠死亡率，抑制循环炎症反应。此外，HS大鼠的主要器官功能，如肝脏和肾脏，在MSCs输注后显著改善。此外，MSCs治疗可明显改善肠粘膜的水肿、坏死和绒毛脱落，减轻肠组织的炎症反应。提示MSC输注对HS大鼠有治疗作用，其机制可能与调节循环和肠道炎症反应有关。此外，骨髓间充质干细胞可能具有保护HS器官功能、促进组织修复的作用。本研究结果表明，骨髓间充质干细胞可作为治疗HS及其引起的器官功能障碍的一种潜在方法。
Heat stroke (HS) is considered to be a severe systemic inflammatory reaction disease that is caused by high fever. The mortality of HS is high worldwide due to the lack of effective treatments. Presently, mesenchymal stem cells (MSCs) have been demonstrated to serve roles in inflammation and immune regulation. Therefore, the current study aimed to investigate the protective effect and mechanism of MSCs against the HS-induced inflammatory response and organ dysfunction. A rat model of HS was induced by a high-temperature environment and treated with MSCs via tail veins. The levels of molecular markers of organ function, inflammatory factors and chemokines were examined at days 1, 7, 14 and 28. Histological staining was performed on the intestines of rats and control groups, and the Chiu's scores of the two groups were compared. The results revealed that MSCs injection significantly reduced the mortality and inhibited the circulatory inflammatory response. Additionally, main organ function, such as in the liver and kidney, were significantly improved following MSCs infusion in HS rats. Furthermore, MSCs treatment significantly improved edema, necrosis and villus exfoliation of intestinal mucosa, and reduced the inflammatory response of intestinal tissue. These results indicated that MSC infusion had therapeutic effects on HS of rats by regulating the circulatory and intestinal inflammatory response. Moreover, MSCs may be able to protect organ function and promote tissue repair in HS. The results of the current study indicated that MSCs may be used as a potential method to treat HS and the resulting organ dysfunction.
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影响因子：
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作者：
Alexis Kagiliery-Lee;Jan Null
通讯作者：
Alexis Kagiliery-Lee;Jan Null
间充质干细胞刺激肠道干细胞修复辐射引起的肠道损伤。
影响因子：
9
作者：
通讯作者：
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影响因子：
4.3
作者：
Penha EM;Meira CS;Guimarães ET;Mendonça MV;Gravely FA;Pinheiro CM;Pinheiro TM;Barrouin-Melo SM;Ribeiro-Dos-Santos R;Soares MB
通讯作者：
Soares MB
影响因子：
3.8
作者：
Alain Zgheib;Émilie Pelletier-Bonnier;Louis-Charles Levros;B. Annabi
通讯作者：
Alain Zgheib;Émilie Pelletier-Bonnier;Louis-Charles Levros;B. Annabi
影响因子：
82.9
作者：
通讯作者：
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