Comparison of the nuclear matrix protein 22 with voided urine cytology and BTA stat test in the diagnosis of transitional cell carcinoma of the bladder
Comparison of the nuclear matrix protein 22 with voided urine cytology and BTA stat test in the diagnosis of transitional cell carcinoma of the bladder
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DOI：
10.1159/000068002
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发表时间：
1999-09-01
期刊：
影响因子：
23.4
通讯作者：
Bozkirli, I
中科院分区：
文献类型：
--
作者：
Sözen, S;Biri, H;Bozkirli, I
目的：评价核基质蛋白22 （nuclear matrix protein 22, NMP22）检测、BTA stat检测和细胞学检测在泌尿系统疾病（包括膀胱癌）患者尿液中的敏感性、特异性、准确性、阳性预测值和阴性预测值。方法：140例膀胱癌患者（其中40例膀胱癌患者）提供尿样，将尿样分成适当的等份进行上述各项检查。内窥镜医师、病理学家、细胞学家以及进行BTA stat测试和NMP22测试的人对其他测试的结果不知情。结果：受体操作特征曲线解释确定12.0 U/ml为NMP22检测本组患者膀胱移行细胞癌的最佳参考值。对比结果显示，NMP22和BTA stat检测膀胱癌的敏感性有明显优势（p < 0.01），而细胞学和NMP22检测膀胱癌的特异性优于BTA stat检测（p < 0.05）。结论：NMP22和BTA stat检测结果较泌尿细胞学检测移行细胞癌有显著改善。在本组患者中，NMP22和BTA stat检测移行细胞癌的敏感性是细胞学检测的两倍。当尿液NMP22的临界值为12.0 U/ml时，NMP22的准确性高于其他检测方法（p < 0.05）。
Objective: To assess sensitivity, specificity, accuracy, positive predictive value and negative predictive value of nuclear matrix protein 22 (NMP22) test, BTA stat test and cytology in the urine of patients with a spectrum of urologic conditions, including bladder cancer. Methods: A total of 140 patients (40 with bladder cancer) provided a urine sample which was divided into appropriate aliquots for each of the tests cited above. The endoscopist, pathologist, cytologist and the person performing BTA stat test and NMP22 test were blinded as to the results of the other tests. Results: Receiver-operating characteristics curve interpretation determined that 12.0 U/ml was an optimal reference value for NMP22 to detect transitional cell carcinoma of the bladder in this patient group. Comparative results demonstrate a clear superiority of NMP22 and BTA stat tests in sensitivity in bladder cancer detection (p < 0.01), while cytology and NM P22 were better than BTA stat test in specificity (p < 0.05). Conclusions: NMP22 and BTA stat test results represented significant improvement over urinary cytology for detection of transitional cell carcinoma. The sensitivities of NMP22 and BTA stat tests for detection of transitional cell carcinoma in this group of patients were as much as twice that of cytology. When the cutoff value of urinary NMP22 was set at 12.0 U/ml, NMP22 was more accurate than the other tests (p < 0.05).