Quantitation of echo-contrast effects.
Quantitation of echo-contrast effects.
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回声对比效应的定量。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
S. Feinstein
中科院分区：
文献类型：
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作者：
S. Powsner;M. Keller;J. Saniie;S. Feinstein
随着超声微泡超声心动图造影剂的最新发展，现在尝试定量实际组织灌注是合理的。然而，这需要理解微泡浓度和反射超声信号之间的定量关系。本文描述了（1）超声处理的微泡的基本声学特性，以及（2）这种关系的实验验证，表明超声信号实际上在临界浓度下开始下降，该临界浓度可以基于气泡尺寸进行预测。这些微泡具有基本上是瑞利散射的随机集合的声学性质。信号强度主要由气体的可压缩性决定，而不是流体。此外，气泡直径是决定信号强度的重要因素（六次方依赖性）。而且，因为气泡是随机排列的，所以当与单个气泡反射的信号相比时，反射的信号不如预期的那么大。声学分析的简单体外测试证实了气泡浓度的临界限值，其测量结果导致了对声处理微泡尺寸的预测，该预测在公布值的两个因子内。这种声学分析和确认，沿着正在进行的体内实验，有望使使用超声造影剂的定量区域灌注测量成为可能。
With the recent development of sonicated microbubble echocardiographic contrast agents, it is now reasonable to attempt to quantitate actual tissue perfusion. However, this requires an understanding of the quantitative relationship between microbubble concentrations and the reflected ultrasound signal. This paper describes (1) the basic acoustic properties of sonicated microbubbles, and (2) experimental verification of this relationship, showing that the ultrasound signal actually begins to decrease at a critical concentration that may be predicted based upon bubble size. These microbubbles have acoustic properties that are essentially those of a random collection of Rayleighian scatters. Signal strength is governed primarily by the compressibility of gas, as opposed to fluid. In addition, bubble diameter is an important factor in determining signal strength (sixth power dependence). And, because the bubbles are randomly arranged, the reflected signal is not as great as might be expected, when compared to the signal reflected by a single bubble. A simple in vitro test of the acoustic analysis confirmed the critical limit for bubble concentration, the measurement of which led to a prediction for sonicated microbubble size that is within a factor of two of the published values. This acoustic analysis and confirmation, along with ongoing in vivo experimentation, promises to make possible quantitative regional perfusion measurement employing sonicated contrast agents.